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Departamento de Farmacologia Faculdade de Medicina de Ribeirão Preto

Trabalhos científicos publicados em 2017

Profa. Dra. Alline Cristina de Campos

1.     Antidepressant-like effect of valproic acid—Possible involvement of PI3K/Akt/mTOR pathway

2.     Cannabinoid Modulation of the Stressed Hippocampus

3.     Cannabinoids as Regulators of Neural Development and Adult Neurogenesis

4.     Evidences for the Anti-panic Actions of Cannabidiol

5.     Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice


Prof. Dr. Fernando de Queiróz Cunha

6.     Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

7.     Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxidedependent activation of G protein receptor kinase

8.     Diabetes Mellitus and Sepsis: a Challenging Association

9.     Diosmin reduces chronic constriction injury-induced neuropathic pain in mice

10.   Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment

11.   Leishmania infantum Parasites subvert the host inflammatory response through the adenosine a2a receptor to Promote the establishment of infection

12.   Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents

13.   The aggravation of arthritis by periodontitis is dependent of IL-17 receptor A activation

14.   The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss

15.   Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis

16.   Toll-Like Receptor 2 Is Required for Inflammatory Process Development during Leishmania infantum Infection


Prof. Dr. Fernando Morgan de Aguiar Corrêa

17.   AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats

18.   The medial preoptic area modulates autonomic function under resting and stress conditions


Prof. Dr. Fernando Silva Carneiro

19.   Are the innate and adaptive immune systems setting hypertension on fire?

20.   Erectile Dysfunction in Wistar Audiogenic Rats Is Associated With Increased Cavernosal Contraction and Decreased Neuronal Nitric Oxide Synthase Protein Expression

21.   Ethanol-induced erectile dysfunction and increased expression of proinflammatory proteins in the rat cavernosal smooth muscle are mediated by NADPH oxidase-derived reactive oxygen species

22.   Mitochondrial Dna activates the nlrP3 inflammasome and Predisposes to Type 1 Diabetes in Murine Model


Prof. Dr. Francisco Silveira Guimarães

23.   A novel peptide that improves metabolic parameters without adverse central nervous system effects

24.   A serotonergic déficit in the dorsal periaqueductal gray matter may underpin enhanced panic-like behavior in diabetic rats

25.   Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative

26.   Cannabidiol disrupts the consolidation of specific and generalized fear memories via dorsal hippocampus CB1 and CB2 receptors

27.   Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia

28.   Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders

29.   Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life

30.   Mice lacking interleukin-18 gene display behavioral changes in animal models of psychiatric disorders: Possible involvement of immunological mechanisms

31.   Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders

32.   Repeated treatment with nitric oxide synthase inhibitor attenuates learned helplessness development in rats and increases hippocampal BDNF expression

33.   The Endocannabinoid System and Anxiety

34.   2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex


Prof. Dr. Hélio Zangrossi Júnior

35.   B2-kinin receptors in the dorsal periaqueductal gray are implicated in the panicolytic-like effect of opiorphin

36.   Disinhibition of the rat prelimbic cortex promotes serotonergic activation of the dorsal raphe nucleus and panicolytic-like behavioral effects

37.   Effects of chemical stimulation of the lateral wings of the dorsal raphe nucleus on panic-like defensive behaviors and Fos protein expression in rats

38.   Panicolytic-like action of bradykinin in the dorsal periaqueductal gray through m-opioid and B2-kinin receptors

39.   Participation of dorsal periaqueductal gray 5-HT1A receptors in the panicolytic-like effect of the -opioid receptor antagonist Nor-BNI

40.   Stress, Panic, and Central Serotonergic Inhibition

41.   M-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses


Prof. Dr. José Carlos Farias Alves Filho

42.   Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis

43.   Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis

44.   Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice

45.   IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

46.   Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

47.   Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo

48.   M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection

49.   Pericytes modulate myelination in the central nervous system

50.   Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production

51.   Probucol attenuates overt pain-like behavior and carrageenaninduced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects

52.   SOCS1 is a negative regulator of metabolic reprogramming during sepsis

53.   Targeting IL-33/ST2 signaling: regulation of immune function and analgesia


Prof. Dr. José Eduardo Tanus dos Santos

54.   Angiotensin converting enzyme inhibitors enhance the hypotensive effects of propofol by increasing nitric oxide production

55.   Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases

56.   Dysregulated mitogen-activated protein kinase and matrix metalloproteinase in ethanol-induced cavernosal dysfunction

57.   Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes

58.   Gene–Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril

59.   Impaired xanthine oxidoreductase (XOR)-mediated nitrite reductase activity possibly involved in the lack of antihypertensive effects of XOR inhibitors

60.   Inducible Nitric Oxide Synthase Polymorphisms and Nitric Oxide Levels in Individuals with Chronic Periodontitis

61.   Influence of arginase polymorphisms and arginase levels/activity on the response to erectile dysfunction therapy with sildenafil

62.   Mechanisms contributing to increased cardiovascular risk in patients taking proton pump inhibitors

63.   Myeloperoxidase in Hypertensive Disorders of Pregnancy and Its Relation With Nitric Oxide

64.   Nitrate decreases xanthine oxidoreductase-mediated nitrite reductase activity and attenuates vascular and blood pressure responses to nitrite

65.   Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy


Prof. Dr. Leonardo Resstel Barbosa Moraes

66.   A single episode of high intensity sound inhibits long-term potentiation in the hippocampus of rats

67.   Bed nucleus of the stria terminalis NMDA receptors and nitric oxide modulate contextual fear conditioning in rats

68.   Glutamatergic, GABAergic, and endocannabinoid neurotransmissions within the dorsal hippocampus modulate the cardiac baroreflex function in rats

69.   Hippocampal subareas arranged in the dorsoventral axis modulate cardiac baroreflex function in a site-dependent manner in rats

70.   Modulation of experimental arthritis by vagal sensory and central brain stimulation

71.   N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus


Profa. Dra. Michele Mazzaron de Castro

72.   Long-Term Excessive Selenium Supplementation Induces Hypertension in Rats

73.   Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling

74.   Metabolic parameters and responsiveness of isolated iliac artery in LDLr-/- mice: role of aerobic exercise training

75.   The potential of stimulating nitric oxide formation in the treatment of hypertension


Prof. Dr. Norberto Cysne Coimbra

76.   CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial división of the ventromedial hypothalamus

77.   Connexions between the dorsomedial división of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour

78.   Critical neuropsychobiological analysis of panic attack-and anticipatory anxiety-like behaviors in rodents confronted with snakes in poligonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests

79.   Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited by GABAergic tonic inhibition impairment in the posterior hypothalamus

80.   New ethological and morphological perspectives for the investigation of panicolytic-like effects of cannabidiol

81.   Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments

82.   Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus

83.   The rodent-versus-wild snake paradigm as a model for studying anxiety-and panic-like behaviors: face, construct and predictive validities

84.   Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours

85.   5-hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus

86.   5-hydroxytryptamine 2A/2C receptors of nucleus haphe magnus and gigantocellularis/paragigantocellularis pars alfa reticular nuclei modulate the unconditioned fear-induced antinociception evoked by electrical stimulation of deep layers of the superior colliculus and dorsal periaqueductal grey matter


Profa. Dra. Rita de Cássia Aleixo Tostes Passaglia

87.   Angeli’s Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta

88.   Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

89.   Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms

90.   Elastase-2, an angiotensin II-generating enzyme, contributes to increased angiotensin II in resistance arteries ofmicewithmyocardial infarction

91.   Glycosylation with O-Linked β-N-acetylglucosamine (OGlcNAc) induces vascular dysfunction via production of superoxide anion / reactive oxygen species

92.   Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice

93.   Increased O-Linked N-Acetylglucosamine Modification of NF-ΚB and Augmented Cytokine Production in the Placentas from Hyperglycemic Rats

94.   Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice

95.   NLRP3 inflammasome: from pathogenesis to therapeutic strategies in type 1 diabetes


Prof. Dr. Thiago Mattar Cunha

96.   Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation

97.   Chronic restraint stress increases angiotensin II potency in the rat carotid: role of cyclooxygenases and reactive oxygen species

98.   CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization

99.   Dor Inflamatória – Capítulo 23 de Tratado de Dor

100.Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation

101.Inhibition of 5-lipoxygenase alleviates graft-versus-host disease

102.Neuroimmune–Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia

103.Neuroimmune regulation of pain and inflammation: targeting glial cells and nociceptor sensory neurons interaction

104.The sesquiterpene lactone, budlein A, inhibits antigen-induced arthritis in mice: role of NF-KB and cytokines

105.Tumor necrosis factor-a receptor 1 contributes to ethanol-induced vascular reactive oxygen species generation and hypertension


Prof. Dr. Wiliam Alves do Prado

106.Angiotensin AT1 receptors modulate the anxiogenic effects of angiotensin (5–8) injected into the rat ventrolateral periaqueductal gray

107.Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats

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