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Departamento de Farmacologia Faculdade de Medicina de Ribeirão Preto



Trabalhos científicos publicados em 2017

Profa. Dra. Alline Cristina de Campos

  1. Antidepressant-like effect of valproic acid—Possible involvement of PI3K/Akt/mTOR pathway
    Cannabinoid Modulation of the Stressed Hippocampus
    Cannabinoids as Regulators of Neural Development and Adult Neurogenesis
    Evidences for the Anti-panic Actions of Cannabidiol
    Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice

Prof. Dr. Fernando de Queiróz Cunha

  1. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
  2. Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxidedependent activation of G protein receptor kinase
  3. Diabetes Mellitus and Sepsis: a Challenging Association
  4. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice
  5. Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment
  6. Leishmania infantum Parasites subvert the host inflammatory response through the adenosine a2a receptor to Promote the establishment of infection
  7. Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents
  8. The aggravation of arthritis by periodontitis is dependent of IL-17 receptor A activation
  9. The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss
  10. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis
  11. Toll-Like Receptor 2 Is Required for Inflammatory Process Development during Leishmania infantum Infection

Prof. Dr. Fernando Morgan de Aguiar Corrêa

  1. AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats
  2. The medial preoptic area modulates autonomic function under resting and stress conditions

Prof. Dr. Fernando Silva Carneiro

  1. Are the innate and adaptive immune systems setting hypertension on fire?
  2. Erectile Dysfunction in Wistar Audiogenic Rats Is Associated With Increased Cavernosal Contraction and Decreased Neuronal Nitric Oxide Synthase Protein Expression
  3. Ethanol-induced erectile dysfunction and increased expression of proinflammatory proteins in the rat cavernosal smooth muscle are mediated by NADPH oxidase-derived reactive oxygen species
  4. Mitochondrial Dna activates the nlrP3 inflammasome and Predisposes to Type 1 Diabetes in Murine Model

Prof. Dr. Francisco Silveira Guimarães

  1. A novel peptide that improves metabolic parameters without adverse central nervous system effects
  2. A serotonergic déficit in the dorsal periaqueductal gray matter may underpin enhanced panic-like behavior in diabetic rats
  3. Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative
  4. Cannabidiol disrupts the consolidation of specific and generalized fear memories via dorsal hippocampus CB1 and CB2 receptors
  5. Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia
  6. Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
  7. Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
  8. Mice lacking interleukin-18 gene display behavioral changes in animal models of psychiatric disorders: Possible involvement of immunological mechanisms
  9. Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders
  10. Repeated treatment with nitric oxide synthase inhibitor attenuates learned helplessness development in rats and increases hippocampal BDNF expression
  11. The Endocannabinoid System and Anxiety
  12. 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex

Prof. Dr. Hélio Zangrossi Júnior

  1. B2-kinin receptors in the dorsal periaqueductal gray are implicated in the panicolytic-like effect of opiorphin
  2. Disinhibition of the rat prelimbic cortex promotes serotonergic activation of the dorsal raphe nucleus and panicolytic-like behavioral effects
  3. Effects of chemical stimulation of the lateral wings of the dorsal raphe nucleus on panic-like defensive behaviors and Fos protein expression in rats
  4. Panicolytic-like action of bradykinin in the dorsal periaqueductal gray through m-opioid and B2-kinin receptors
  5. Participation of dorsal periaqueductal gray 5-HT1A receptors in the panicolytic-like effect of the -opioid receptor antagonist Nor-BNI
  6. Stress, Panic, and Central Serotonergic Inhibition
  7. M-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses

Prof. Dr. José Carlos Farias Alves Filho

  1. Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis
  2. Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis
  3. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice
  4. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
  5. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
  6. Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo
  7. M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection
  8. Pericytes modulate myelination in the central nervous system
  9. Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production
  10. Probucol attenuates overt pain-like behavior and carrageenaninduced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects
  11. SOCS1 is a negative regulator of metabolic reprogramming during sepsis
  12. Targeting IL-33/ST2 signaling: regulation of immune function and analgesia

Prof. Dr. José Eduardo Tanus dos Santos

  1. Angiotensin converting enzyme inhibitors enhance the hypotensive effects of propofol by increasing nitric oxide production
  2. Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases
  3. Dysregulated mitogen-activated protein kinase and matrix metalloproteinase in ethanol-induced cavernosal dysfunction
  4. Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes
  5. Gene–Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril
  6. Impaired xanthine oxidoreductase (XOR)-mediated nitrite reductase activity possibly involved in the lack of antihypertensive effects of XOR inhibitors
  7. Inducible Nitric Oxide Synthase Polymorphisms and Nitric Oxide Levels in Individuals with Chronic Periodontitis
  8. Influence of arginase polymorphisms and arginase levels/activity on the response to erectile dysfunction therapy with sildenafil
  9. Mechanisms contributing to increased cardiovascular risk in patients taking proton pump inhibitors
  10. Myeloperoxidase in Hypertensive Disorders of Pregnancy and Its Relation With Nitric Oxide
  11. Nitrate decreases xanthine oxidoreductase-mediated nitrite reductase activity and attenuates vascular and blood pressure responses to nitrite
  12. Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy

Prof. Dr. Leonardo Resstel Barbosa Moraes

  1. A single episode of high intensity sound inhibits long-term potentiation in the hippocampus of rats
  2. Bed nucleus of the stria terminalis NMDA receptors and nitric oxide modulate contextual fear conditioning in rats
  3. Glutamatergic, GABAergic, and endocannabinoid neurotransmissions within the dorsal hippocampus modulate the cardiac baroreflex function in rats
  4. Hippocampal subareas arranged in the dorsoventral axis modulate cardiac baroreflex function in a site-dependent manner in rats
  5. Modulation of experimental arthritis by vagal sensory and central brain stimulation
  6. N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus

Profa. Dra. Michele Mazzaron de Castro

  1. Long-Term Excessive Selenium Supplementation Induces Hypertension in Rats
  2. Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling
  3. Metabolic parameters and responsiveness of isolated iliac artery in LDLr-/- mice: role of aerobic exercise training
  4. The potential of stimulating nitric oxide formation in the treatment of hypertension

Prof. Dr. Norberto Cysne Coimbra

  1. CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial división of the ventromedial hypothalamus
  2. Connexions between the dorsomedial división of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour
  3. Critical neuropsychobiological analysis of panic attack-and anticipatory anxiety-like behaviors in rodents confronted with snakes in poligonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests
  4. Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited by GABAergic tonic inhibition impairment in the posterior hypothalamus
  5. New ethological and morphological perspectives for the investigation of panicolytic-like effects of cannabidiol
  6. Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments
  7. Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus
  8. The rodent-versus-wild snake paradigm as a model for studying anxiety-and panic-like behaviors: face, construct and predictive validities
  9. Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours
  10. 5-hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus
  11. 5-hydroxytryptamine 2A/2C receptors of nucleus haphe magnus and gigantocellularis/paragigantocellularis pars alfa reticular nuclei modulate the unconditioned fear-induced antinociception evoked by electrical stimulation of deep layers of the superior colliculus and dorsal periaqueductal grey matter

Profa. Dra. Rita de Cássia Aleixo Tostes Passaglia

  1. Angeli’s Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta
  2. Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy
  3. Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms
  4. Elastase-2, an angiotensin II-generating enzyme, contributes to increased angiotensin II in resistance arteries ofmicewithmyocardial infarction
  5. Glycosylation with O-Linked β-N-acetylglucosamine (OGlcNAc) induces vascular dysfunction via production of superoxide anion / reactive oxygen species
  6. Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice
  7. Increased O-Linked N-Acetylglucosamine Modification of NF-ΚB and Augmented Cytokine Production in the Placentas from Hyperglycemic Rats
  8. Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice
  9. NLRP3 inflammasome: from pathogenesis to therapeutic strategies in type 1 diabetes

Prof. Dr. Thiago Mattar Cunha

  1. Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
  2. Chronic restraint stress increases angiotensin II potency in the rat carotid: role of cyclooxygenases and reactive oxygen species
  3. CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization
  4. Dor Inflamatória – Capítulo 23 de Tratado de Dor
  5. Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation
  6. Inhibition of 5-lipoxygenase alleviates graft-versus-host disease
  7. Neuroimmune–Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia
  8. Neuroimmune regulation of pain and inflammation: targeting glial cells and nociceptor sensory neurons interaction
  9. The sesquiterpene lactone, budlein A, inhibits antigen-induced arthritis in mice: role of NF-KB and cytokines
  10. Tumor necrosis factor-a receptor 1 contributes to ethanol-induced vascular reactive oxygen species generation and hypertension

Prof. Dr. Wiliam Alves do Prado

  1. Angiotensin AT1 receptors modulate the anxiogenic effects of angiotensin (5–8) injected into the rat ventrolateral periaqueductal gray
  2. Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats


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