Site da USP
Departamento de Farmacología Facultad de Medicina de Ribeirão Preto

Publicaciones

201520142013

Prof. Dr. Alexandre Pinto Corrado

  1. Prado, W. A.; Rossaneis, A. C.; Carvalho, I.; Zamoner, L. O. & Corrado, A. P.: Neamine and 2-deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic pain. J Pharm Pharmacol., 67, 1696-1704.

  2. Oliveira, L.; Costa, A. C.; Noronha-Matos, J. B.; Silva, I.; Cavalcante, W. L.; Timoteo, M. A.; Corrado, A. P.; Dal Belo, C. A.; Ambiel, C. R.; Alves-Do-Prado, W. & Correia-De-Sa, P.: Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A2A receptors and redistribution of synaptic vesicles. Neuropharmacology. v.89 64-76.

Profa. Dra. Alline Cristina de Campos

  1. De Miranda, A. S.; Brant, F.; Campos, A. C.; Vieira, L. B.; Rocha, N. P.; Cisalpino, D.; Binda, N. S.; Rodrigues, D. H.; Ransohoff, R. M.; Machado, F. S.; Rachid, M. A. & Teixeira, A. L.: Evidence for the contribution of adult neurogenesis and hippocampal cell death in experimental cerebral malaria cognitive outcome. Neuroscience. v.284 920-33.

  2. Lima, I. V.; Campos, A. C.; Miranda, A. S.; Vieira, E. L.; Amaral-Martins, F.; Vago, J. P.; Santos, R. P.; Sousa, L. P.; Vieira, L. B.; Teixeira, M. M.; Fiebich, B. L.; Moraes, M. F.; Teixeira, A. L. & De Oliveira, A. C.: PI3Kgamma deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. Exp Neurol. v.267 123-34.

  3. Campos, A. C.; Brant, F.; Miranda, A. S.; Machado, F. S. & Teixeira, A. L.: Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience. v.289 166-80.

Prof. Dr. Fernando de Queiróz Cunha

  1. Bassi, G.S.; Brognara, F.; Castania, J.A.; Talbot, J.; Cunha, T.M.; Cunha, F.Q.; Ulloa, L.; Kanashiro, A.; Dias, D.P.M. & Salgado, H.C. Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function. Brain, Behavior & Immunity, 49: 140-147, 2015

  2. Borghi, S.M.; Pinho-Ribeiro, F.A.; Zarpelon, A.C.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice. Exp. Physiol., 100(5): 531-544, 2015.

  3. Cardoso, C.P.; De Oliveira, A.J.A.; Botoni, F.A.; Rezende, I.C.P.; Alves-Filho, J.C.; Cunha, F.Q.; Estanislau, J.A.S.; Magno, L.A.V. & Rios-Santos, F. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock. Mem. Inst. Oswaldo Cruz, RJ, 110(4): 453-460, 2015.

  4. Carlos, D.; Yaochite, J.N.U.; Rocha, F.A.; Toso, V.D.; Malmegrim, K.C.R.; Ramos, S.G.; Jamur, M.C.; Oliver, C.; Camara, N.O.; Andrade, M.V.M.; Cunha F.Q. & Silva, J.S. Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice. Eur. J. Immunol., 45(10): 2873-2885, 2015.

  5. Carregaro, V.; Ribeiro, J.M.; Valenzuela, J.G.; Souza-Júnior, D.L.; Costa, D.L.; Oliveira, C.J.F.; Sacramento, L.A.; Nascimento, M.S.L.; Milanezi, C.M.; Cunha, F.Q. & Silva, J.S. Nucleosides present of phlebotomine saliva induce immunossuppression and promote the infection establishment. PLoS Negl. Trop. Dis., 9(4): e0003600, pgs: 1 a 21, 2015.

  6. Carvalho, T.T.; Borghi, S.M.; Pinho-Ribeiro, F.A.; Mizokami, S.S.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: role for peripheral TNFα, IL-1β and IL-10. Eur. J. Pharmacol., 749: 62-72, 2015.

  7. Conte, F.P.; Ferraris, F.K.; Costa, T.E.M.M.; Pacheco, P.; Seito, L.N.; Verri Jr., W.A.; Cunha, F.Q.; Penido, C. & Henriques, M.G. Effect of gedunin on acute articular inflammation and hypernociception in mice. Molecules 20(2): 2636-2657, 2015.

  8. Fattori, V.; Pinho-Ribeiro, F.A.; Borghi,S.M.; Alves-Filho, J.C.; Cunha, T.M.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NK-кB activation. Inflamm. Res., 64(12): 993-1003, 2015.

  9. Freitas, C.S.; Roveda, A.C., Jr.; Truzzi, D.R.; Garcia, A.C.; Cunha, T.M.; Cunha, F.Q. & Franco, D.W. Anti-inflammatory and anti-nociceptive activity of ruthenium complexes with isonicotinic and nicotinic acids (Niacin) as ligands. J. Med. Chem., 58(11): 4439-4448, 2015.

  10. Gaspar-Elsas, M.I.; Queto, T.; Masid-de-Brito, D.; Vieira, B.M.; De Luca, B.; Cunha, F.Q. & Xavier-Elsas, P. α-Galactosylceramide suppresses murine eosinophil production through interferon-y-dependent induction of NO synthase and CD95. Br. J. Pharmacol., 172(13): 3313-3325, 2015.

  11. Leite, C.A.V.G.; Alencar, V.T.L.; Melo, D.L.R.; Mota, J.M.S.C.; Melo, P.H.; Mourão, L.T.C.; Wong, D.V.T.; Magalhães, P.J.C.; Santos, A.A.; Brito, G.A.C.; Lima-Júnior, R.C.P.; Cunha, F.Q. & Ribeiro, R.A. Target inhibition of IL-1 receptor prevents ifosfamide induced hemorrhagic cystitis in mice. J. Urol., 194(6): 1777-1786, 2015.

  12. Molinaro, R.; Pecli, C.; Guilherme, R.F.; Alves-Filho, J.C.; Cunha, F.Q.; Canetti, C.; Kunkel, S.L.; Bozza, M.T. & Benjamim, C.F. CCR4 controls the suppressive effects of regulatory T cells on early and late events during severe sepsis. PLoS ONE, 10(7): e0133227, 1-21, 2015.

  13. Moura, J.F.B.; Mota, J.M.S.C.; Leite, C.A.V.; Wong, D.V.T.; Bezerra, N.P.; Brito, G.A.C.; Lima, V.; Cunha, F.Q. & Ribeiro, R.A. A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide. Int. J. Radiat. Biol., 91(6): 500-509, 2015.

  14. Nunes, R.M.; Martins, M.R.; Silva-Junior, F.S..; Leite, A.C.R.M.; Girão, V.C.C.; Cunha, F.Q.; Marinho, A.L.L.F.; Pinto, A.C.M.D. & Rocha, F.A.C. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflamm. Res., 64(10): 781-787, 2015.

  15. Peres. R.S.; Liew, F.Y.; Talbot, J.; Carregaro, V.; Oliveira, R.D.; Almeida, S.L.; França R.F.O.; Donate, P.B.; Pinto, L.G.; Ferreira, F.I.S.; Costa, D.L.; Demarque, D.P.; Gouvea, D.R.; Lopes, N.P.; Queiroz, R.H.C.; Silva, J.S.; Figueiredo, F.; Alves-Filho, J.C.; Cunha, T.M.; Ferreira, S.H.;; Louzada-Junior, P. & Cunha, F.Q. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. PNAS 112(8): 2509-2514, 2015.

  16. Pinto, L.G.; Talbot, J.; Peres, R.S.; França, R.F.; Ferreira, S.H.; Ryffel, B.; Alves-Filho, J.C.; Figueiredo, F.; Cunha, T.M. & Cunha, F.Q. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production. Arthritis Res. & Therapy, 17(1): 235: 1-13, 2015.

  17. Ruiz-Miyazawa, K.W.; Pinho-Ribeiro, F.a.; Zarpelon, A.C.; Staurengo-Ferrari, L.; Silva, R.L.; Alves-Filho, J.C.; Cunha, T.M.; Cunha. F.Q.; Casagrande, R. & Verri Jr., W.A. Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-кB. Chem. Biol. Interact., 237: 9-17, 2015.

  18. Sacramento, L.; Trevelin, S.c.; Nascimento, M.S.; Lima-Júnior, D.S.; Costa, D.L.; Almeida, R.P.; Cunha, F.Q.; Silva, J.S. & Carregaro, V. Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection. Infect. Immun., 83(12): 4604-4616, 2015.

  19. Serafim, K.G.G.; Navarro, S.A.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Fattori, V.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice. Naunyn-Schmiedeb. Arch. Pharmacol., 388(11): 1211-1221, 2015.

  20. Souza, G.R.; Cunha, T.M.; Silva, R.L.; Lotufo, C.M.; Verri, W.A., Jr.; Funez, M.I.; Villarreal, C.F.; Talbot, J.; Sousa, L.P.; Parada, C.A.; Cunha, F.Q. & Ferreira, S.H. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacol. Biochem. & Beh., 134: 49-56, 2015.

  21. Wong, D.V.T.; Lima-Júnior, R.C.P.; Carvalho, C.B.M.; Borges, V.F.; Wanderley, C.W.S.; Bem, A.X.C.; Leite, C.A.V.G.; Teixeira, M.A.; Batista, G.L.P.; Silva, R.L.; Cunha, T.M.; Brito, G.A.C.; Almeida, P.R.C.; Cunha, F.Q. & Ribeiro, R.A. The adaptor protein Myd88 is a key signaling molecule in the pathogenesis of irinotecan-induced intestinal mucositis. PLoS One 10(10): e0139985, 1-21, 2015.

  22. Xavier-Elsas, P.; De Luca, B.; Queto, T.; Vieira, B.M.; Masid-de-Brito, D.; Dahab, E.C.; Alves-Filho, J.C.F.; Cunha, F.Q. & Gaspar-Elsas, M.I.C. Blockage of eosinopoiesis by IL-17A is prevented by cytokine and lipid mediators of allergic inflammation. Med. Inflamm.; Volume 2015, Article ID 968932: 1-11, 2015.

Prof. Dr. Fernando Morgan de Aguiar Corrêa

  1. Fassini, A.; Scopinho, A.A.; Resstel, L.B.M. & Corrêa, F.M.A. k-Opioid receptors in the infralimbic córtex modulate the cardiovascular resnses to acute stress. Exp. Physiol.; 100(4): 377-387, 2015.

  2. Fortaleza, E.A.T.; Ferreira-Junior, N.C.; La Gatta, D.C.; Resstel, L.B.M. & Corrêa, F.M.A. The medial amygdaloid nucleus modulates the baroreflex activity in conscious rats. Auton. Neurosci., 193: 44-50, 2015.

  3. Pelosi, G.G.; Busnardo, C.; Tavares, R.F. & Corrêa, F.M.A. Involvement of non-NMDA glutamate receptors of the hypothalamic paraventgricular nucleus in the cardiovascular response to the microinjection of noradrenaline into the dorsal periaqueductal gray area of rats. Brain Res., 1602: 96-105, 2015.

  4. Stanquini, L.A.; Resstel, L.B.M.; Corrêa, F.M.A.; Joca, S.R.L. & Scopinho, A.A. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacol., Biochem. Beh., 136: 31-38, 2015.

Prof. Dr. Fernando Silva Carneiro

  1. Muniz, J. J.; Leite, L. N.; De Martinis, B. S.; Carneiro, F. S. & Tirapelli, C. R.: Chronic ethanol consumption induces erectile dysfunction: Role of oxidative stress. Life Sci. v.141 44-53.

  2. Rodrigues, F. L.; Silva, L. E.; Hott, S. C.; Bomfim, G. F.; Da Silva, C. A.; Fazan, R., Jr.; Resstel, L. B.; Tostes, R. C. & Carneiro, F. S.: Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure. Am J Physiol Regul Integr Comp Physiol. v.308 (8): R714-23.

Prof. Dr. Gustavo Ballejo Olivera

  1. Alves Filho, F.; Cavalcanti, P. M.; Passaglia R de, C. & Ballejo, G.: Long-lasting endothelium-dependent relaxation of isolated arteries caused by an extract from the bark of Combretum leprosum. Einstein (Sao Paulo). v.13 (3): 395-403.

Prof. Dr. Hélio Zangrossi Júnior

  1. Bulos, E.M.; Pobbe, R.L.H. & Zangrossi, H., Jr. Behavioral consequences of predator stress in the rat elevated T-maze. Physiol. Behav., 146: 28-35, 2015.

  2. Casarotto, P.C.; dos Santos, P.C.; Lucas, G.A.; Biojone, C.; Pobbe, R.L.H.; Vilela-Costa, H.H.; Joca, S.R.L.; Guimarães, F.S. & Zangrossi, H., Jr. BDNF-TRKB signaling system of the dorsal periaqueductal Gray matter is implicated in the panicolytic-like effect of antidepressant drugs. Eur. Neuropsychopharmacol., 25(6): 913-922, 2015.

  3. Graeff, F.G.; Sant´Anna A.B.; Vilela-Costa, H.H. & Zangrossi, H., Jr. New findings on the neurotransmitter modulation of defense in the dorsal periaqueductal gray. CNS Neurol. Disord. Drug Targets, 14(8): 988-995, 2015.

  4. Roncon, C.M.; Almada, R.C.; Maraschin, J.C.; Audi, E.A.; Zangrossi, H., Jr.; Graeff, F.G. & Coimbra, N.C. Pharmacological evidence for the mediation of the panicolytic effect of fluoxetine by dorsal periaqueductal gray matter µ-opioid receptors. Neuropharmacol., 99: 620-626, 2015.

  5. Spiacci, A. Jr.; De-Oliveira-Sérgio, T.; Da Silva, G.S.F.; Glass, M.L.; Schenberg, L.C.; Garcia-Cairasco, N. & Zangrossi, H., Jr. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. Neuroscience, 307: 191-198, 2015.

Prof. Dr. José Carlos Farias Alves Filho

  1. Talbot, J.; Bianchini, F.J.; Nascimento, D.C.; Oliveira, R.D.R.; Souto, F.O.; Pinto, L.G.; Peres, R.S.; Silva, J.R.; Almeida, S.C.L.; Louzada-Junior, P.; Cunha, T.M.; Cunha, F.Q. & Alves-Filho, J.C. CCR2 expression in neutrophils plays a critical role in their migration into the joints in rheumatoid arthritis. Arth. & Rheumat., 67(7): 1751-1759, 2015.

  2. Veras, F.P.; Peres, R.S.; Saraiva, A.L.L.; Pinto, L.G.; Louzada-Junior, P.; Cunha, T.M.; Paschoal, J.A.R.; Cunha, F.Q. & Alves-Filho, J.C. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. Sci Rep., 5: 15171 (1 a 11), 2015.

Prof. Dr. José Eduardo Tanus dos Santos

  1. 1. Amaral, J.H.; Ferreira, G.C.; Pinheiro, L.C.; Montenegro, M.F. & Tanus-Santos, J.E. Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. Redox Biol., 5: 340-346, 2015.

  2. Barbaro, N.R.; Araujo, T.M.; Tanus-Santos, J.E.; Anhê, G.F.; Fontana, V. & Moreno, H. Vascular damage in resistant hypertension: TNF-alpha inhibition effects on endothelial cells. Biomed. Res. Int., vol. 2015, Article ID 631594 (1-8), 2015.

  3. Barcelos, G.R.M.; De Marco, K.C.; De Rezende, V.B.; Braga, G.U.L.; Antunes, L.M.G.; Tanus-Santos, J.E. & Barbosa Jr., F. Genetic effects of eNOS polymorphisms on biomarkers related to cardiovascular status in a population coexposed to methylmercury and lead. Arch. Environ. Contam. Toxicol., 69(2): 173-180, 2015.

  4. Belo, V.A.; Lacchini, R.; Miranda, J.A.; Lanna, C.M.M.; Souza-Costa, D.C. & Tanus-Santos, J.E. Increased activity of MMP-2 in hypertensive obese children is associated with hypoadiponectinemia. Obesity, 23(1): 177-182, 2015.

  5. Belo, V.A.; Luizon, M.R.; Lacchini, R.; Miranda, J.A.; Lanna, C.M.M.; Souza-Costa, D.C. & Tanus-Santos, J.E. The effects of NAMPT haplotypes and metabolic risk factors on circulating visfatin/NAMPT levels in childhood obesity. Internat. J. Obesity, 39(1): 130-135, 2015.

  6. Cau, S.B.A.; Guimarães, D.A.; Rizzi, E.; Ceron, C.S.; Gerlach, R.F. & Tanus-Santos, J.E. The nuclear factor kappaB inhibitor pyrrolidine dithiocarbamate prevents cardiac remodeling and matrix metalloproteinase-2 Up-regulation in renovascular hypertension. Basic & Clinical Pharmacol. & Toxicol.,117(4): 234-241, 2015.

  7. De Faria, A.P.C.; Modolo, R.; Sabbatini, A.R.; Barbaro, N.R.; Corrêa, N.B.; Brunelli, V.; Tanus-Santos, J.E.; Fontana, V. & Moreno, H. Adiponectin -11377C/G and +276G/T polymorphisms affect adiponectin levels but do not modify Responsiveness to therapy in resistant hypertension. Basic & Clinical Pharmacol. & Toxicol., 117(1): 65-72, 2015.

  8. De Miranda, J.A.; Lacchini, R.; Belo, V.A.; Lanna, C.M.M.; Sertorio, J.T.; Luizon, M.R. & Tanus-Santos, J.E. The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents. J. Human Hypertens., 29(2): 109-114, 2015.

  9. Eleutério, N.M.; Palei, A.C.T.; Rangel Machado, J.S.; Tanus-Santos, J.E.; Cavalli, R.C. & Sandrim, V.C. Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant. Pregnancy Hypertens., 5(2): 205-208, 2015.

  10. Guimarães, D.A. & Tanus-Santos, J.E.. Combining drugs to optimize the therapy of hypertension: experimental evidence derived from animal models. Hypertension Res., 38(7): 457-458, 2015.

  11. Guimarães, D.A.; Rizzi, E.; Ceron, C.S.; Martins-Oliveira, A.; Gerlach, R.F.; Shiva, S. & Tanus-Santos, J.E. Atorvastatin and sildenafil decrease vascular TGF-β levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension. Redox Biol., 6: 386-395, 2015.

  12. Lacchini, R.; Muniz, J.J.; Nobre, Y.T.D.A.; Cologna, A.J.; Martins, A.C.P. & Tanus-Santos, J.E. Relationship between arginase 1 and arginase 2 levels and genetic polymorphisms with erectile dysfunction. Nitric Oxide, 51: 36-42, 2015.

  13. Luizon, M.R.; Belo, V.A.; Palei, A.C.T.;Amaral, L.M.; Lacchini, R.; Sandrim, V.C.; Duarte, G.; Cavalli, R.C. & Tanus-Santos, J.E. Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy. Hypertension Res., 38(5): 361-366, 2015.

  14. Oliveira-Paula, G.H.; Lacchini, R.; Fontana, V.; Silva, P.S.; Biagi, C. & Tanus-Santos, J.E. Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril. Eur. J. Clin. Pharmacol., 71(8): 949-957, 2015.

  15. Pinheiro, L.C.; Amaral, J.H.; Ferreira, G.C.; Portella, R.L.; Ceron, C.S.; Montenegro, M.F.; Toledo Jr., J.C. & Tanus-Santos, J.E. Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension. Free Radic. Biol. Med., 87: 252-262, 2015.

  16. Rezende, V.B.; Barbosa Jr., F.; Palei, A.C.T.; Cavalli, R.C.; Tanus-Santos, J.E. & Sandrim, V.C. Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy. J. Trace Elem. Med. Biol., 29: 130-135, 2015.

  17. Rocha, M.G.; Gomes, V.A.; Tanus-Santos, J.E.; Rosa-e-Silva, J.C.; Candido-dos-Reis, F.J.; Nogueira, A.A. & Poli-Neto, O.B. Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis. Braz. J. Med. Biol. Res., 48(4): 363-369, 2015.

  18. Sandrim, V.C.; Palei, A.C.T.; Eleuterio, N.; Tanus-Santos, J.E. & Cavalli, R.C. Antihypertensive therapy in preeclampsia is not modulated by VEGF polymorphisms. Arch. Gynecol. Obstet, 291(4): 799-803, 2015.

Prof. Dr. Leonardo Resstel Barbosa Moraes

  1. Fassini, A.; Antero, L.S.; Corrêa, F.M.A.; Joca, S.R.L. & Resstel, L.B.M. The prelimbic córtex muscarinic M3 receptor-nitric oxide-guanylyl cyclase pathway modulates cardiovascular responses in rats. J. Neurosc. Res., 93(5): 830-838, 2015.

  2. Lagatta, D.C.; Ferreira-Junior, N.C. & Resstel, L.B.M. Medial prefrontal córtex TRPV1 channels modulate the baroreflex cardiac activity in rats. Br. J. Pharmacol., 172: 5377-5389, 2015.

  3. Lisboa, S.F.; Borges, A.A.; Nejo, P.; Fassini, A.; Guimarães, F.S. & Ressel, L.B.M. Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefronal córtex modulate anxiety-lkike behavior in rats: Additional evidence. Prog. Neuro-Psychopharmacol. & Biol. Psychiatry, 59: 76-83, 2015.

  4. Lisboa, S.F.; Gomes, F.V.; Silva, A.L.S.; Uliana, D.L.; Camargo, L.H.A.; Guimarães, F.S.; Cunha, F.Q.; Joca, S.R.L. & Resstel, L.B.M. Increased contextual fear conditioning in iNOS knockout mice: Additional evidence for the involvement of nitric oxide in stress-related disorders and contribution of the endocannabinoid system. Int. J. Neuropsyhopharmacol., 18(8): 1-12, 2015.

  5. Simplicio, J.A.; Resstel, L.B.M.; Tirapelli, D.P.C.; D´Orléans-Juste, P. & Tirapelli, C.R. Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vasc. Pharmacol., 73: 124-137, 2015.

  6. Stanquini, L.A.; Resstel, L.B.M.; Corrêa, F.M.A.; Joca, S.R.L. & Scopinho, A.A. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacol., Biochem. Beh., 136: 31-38, 2015.

  7. Viana, T.G.; Hott, S.C.; Resstel, L.B.M.; Aguiar, D.C. & Moreira, F.A. Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats. Psychopharmacol., 232(9): 1545-1553, 2015.

Profa. Dra. Michele Mazzaron de Castro

  1. Belo, V.A. & Castro, M.M. Matrix metalloproteinases and the vascular smooth muscle cell migration in hypertension. Diabesity 1(2): 15-17, 2015.

  2. Belo, V.A.; Guimarães, D.A. Castro, M.M. Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension. J. Vasc. Res., 52(4): 221-231, 2015.

Prof. Dr. Norberto Cysne Coimbra

  1. Almada, R.C. & Coimbra, N.C. Recruitment os striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae). Synapse 69(6): 299-313, 2015.

  2. Almada, R.C.; Coimbra, N.C. & Brandão, M.L. Medial prefrontal córtex serotonergic and GABAergic mechanisms modulate the expression of contextual fear: intraatelencephalic pathways and differential involvement of cortical subregions. Neurosc., 284: 988-997, 2015.

  3. Almada, R.C.; Roncon, C.M.; Elias-Filho, D.H. & Coimbra, N.C. Endocammabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by Urutu-cruzeiro venomous pit viper. Neurosc., 303: 503-514, 2015.

  4. Roncon, C.M.; Almada, R.C.; Maraschin, J.C.; Audi, E.A.; Zangrossi, H., Jr.; Graeff, F.G. & Coimbra, N.C. Pharmacological evidence for the mediation of the panicolytic effect of fluoxetine by dorsal periaqueductal gray matter µ-opioid receptors. Neuropharmacol., 99: 620-626, 2015.

  5. Silva, J.A.; Biagioni, A.F.; Almada, R.C.; Crippa, J.A.S.; Hallak,. J.E.C.; Zuardi, A.W. & Coimbra, N.C. Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulate, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon. Eur. J. Pharmacol., 758: 153-163, 2015.

  6. Twardowschy, A. & Coimbra, N.C. µ- and к-Opioid receptor activation in the dorsal periaqueductal grey matter differentially modulates panic-like behaviours induced by electrical and chemical stimulation of the inferior colliculus. Brain Res., 1597: 168-179, 2015.

  7. Ullah, F.; Dos Anjos-Garcia, T.; Santos, I.R.; Biagioni, A.F. & Coimbra, N.C. Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors. Beh. Brain Res., 293: 143-152, 2015.

Profa. Dra. Rita de Cássia Aleixo Tostes Passaglia

  1. Bomfim, G.F.; Echem, E.; Martins, C.B.; Costa, T.J.; Sartoretto, S.M.; Dos Santos, R.A.; Oliveira, M.A.; Akamine, E.H.; Fortes, Z.B.; Tostes, R.C.; Webb, R.C. & Carvalho, M.H.C. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci., 122: 1-7, 2015.

  2. Bruder-Nascimento, T.; Callera, G.E.; Montezano, A.C.; He, Y.; Antunes, T.T.; Cat, A.N.; Tostes, R.C. & Touyz, R.M. Vascular injury in diabetic dB/dB mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways. Clin. Sci. (Lond)., 128(7): 411-423, 2015.

  3. Chignalia, A.Z.; De Oliveira, M.A.; Debbas, V.; Dull, R.O.; Laurindo, F.R.M.; Touyz, R.M.; Carvalho, M.H.C.; Fortes, Z.B. & Tostes, R.C. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clin. Sci., 129(1): 39-48, 2015.

  4. Costa, T.J.; Ceravolo, G.S.; Dos Santos, R.A.; De Oliveira, M.A.; Araújo, P.X.; Giaquinto, L.R.; Tostes, R.C.; Akamine, E.H.; Fortes, Z.B.; Dantas, A.P. & Carvalho, M.H.C. Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells. Am. J. Physiol. Heart Circ. Physiol., 308(7): H723-H732, 2015.

  5. Ferreira, N.S.; Cau, S.B.A.; Silva, M.A.B.; Manzato, C.P.; Mestriner, F.L.A.C.; Matsumoto,T.; Carneiro, F.S. & Tostes, R.C. Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation. Frontiers in Pharmacol., vol. 6, Article 34, pags. 1-12, 2015.

  6. Lopes, R.A.; Neves, K.B.; Tostes, R.C.; Montezano, A.C. & Touyz, R.M. Downregulation of nuclear factor erythroid 2-related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 66(6): 1240-1250, 2015.

  7. Matsumoto, T.; Goulopoulou, S.; Taguchi, K.; Tostes, R.C. & Kobayashi, T. Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Brit. J. Pharmacol., 172(16): 3980-4001, 2015.

  8. Neves, K.B.; Dinh Cat, A.N.; Lopes, R.A.M.; Rios, F.J.; Anagnostopoulou, A.; Lobato, N.S.; De Oliveira, A.M.; Tostes, R.C.; Montezano, A.C. & Touyz, R.M. Chemerin regulates crosstalk between adipocytes and vascular cells through nox. Hypertension, 66(3): 657-666, 2015.

  9. Pereira, C.A.; Ferreira, N.S.; Mestriner, F.L.; Antunes-Rodrigues, J.; Évora, P.R.B.; Resstel, L.B.M.; Carneiro, F.S. & Tostes, R.C. Chronic fluoxetine treatment increases NO bioavailability and calcium-sensitive potassium channels activation in rat mesenteric resistance arteries. Eur. J. Pharmacol., 765: 375-383, 2015.

  10. Rodrigues, F.L. Fais, R.S. Tostes, R.C. & Carneiro, F.S. There is a link between erectile dysfunction and heart failure: it could be inflammation. Curr. Drug Targets, 16(5): 442-450, 2015.

  11. Silva, M.A.B.; Brude-Nascimento, T.; Cau, S.B.A.; Lopes.,R.A.M.; Mestriner, F.L.A.C.; Fais, R.S.; Toyyz, R.M. & Tostes, R.C. Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling. Frontiers in Physiol., Vol. 6: Article 269 (1-11), 2015.

  12. Silva, M.A.B.; Cau, S.B.A.; Lopes, R.A.M.; Manzato, C.P.; Neves, K.B.; Bruder-Nascimento, T.; Mestriner, F.L.A.C.; Montezano, A.C.; Dinh Cat, A.N.; Touyz, R.M. & Tostes, R.C. Mineralocorticoid receptor blockade prevents vascular remodeling in a rodent model of type 2 diabetes mellitus. Clin. Sci., 129(7): 533-545, 2015.

Prof. Dr. Thiago Mattar Cunha

  1. Fonseca, M.D.; Cunha, F.Q.; Kashfi, K. & Cunha, T.M. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. Pharmacol. Res. Perspec., 3(3): e00133 (1-12), 2015.

  2. Lopes, A.H.; Talbot, J.; Silva, R.L.; Lima, J.B.; França, R.O.; Verri, W.A., Jr.; Mascarenhas, D.P.; Ryffel, B.; Cunha, F.Q.; Zamboni, D.S. & Cunha, T.M. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain, 156(3): 451-459, 2015.

  3. Parra, R.S.; Lopes, A.H.; Carreira, E.U.; Feitosa, M.R.; Cunha, F.Q.; Garcia, S.B.; Cunha, T.M.; da Rocha, J.J.R. & Féres, O. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. Medical Gas Res., 5: 6 (1-9), 2015.

  4. Patricio, E.S.; Costa, R.; Figueiredo, C.P.; Gers-Barlag, K.; Bicca, M.A.; Manjavachi, M.N.; Segat, G.C.; Gentry, C.; Luiz, A.P.; Fernandes,. E.S.; Cunha, T.M.; Bevan, S. & Calixto, J.B. Mechanisms Underlying the scratching behavior induced by the activation of proteinase-activated receptor-4 in mice. J. Investig. Dermatol., 135(10): 2484-2491, 2015.

  5. Quadros, A.U.; Pinto, L.G.; Fonseca, M.M.; Kusuda, R.; Cunha, F.Q. & Cunha, T.M. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. Scientific Rep., 5: 14648 (1-11), 2015.

  6. Silva, R.L.; Lopes, A.H.; França, R.O.; Vieira, S.M.; Silva, E.C.C.; Amorim, R.C.N.; Cunha, F.Q.; Pohlit, A.M. & Cunha, T.M. The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation. J. Nat. Prod., 78(2): 241-249, 2015.

  7. Toller-Kawahisa, J.E.; Canicoba, N.C.; Venancio, V.P.; Kawahisa, R.; Antunes, L.M.G.; Cunha, T.M. & Marzocchi-Machado, C.M. Systemic lupus erythematosus onset in lupus-prone B6.MRL/lpr mice Is influenced by weight gain and Is preceded by an increase in neutrophil oxidative burst activity. Free Rad. Biol. Med., 86: 362-373, 2015.

  8. Vaz, E.R.; Fujimura, P.T.; Araujo, G.R.; Silva, C.A.T.; Silva, R.L.; Cunha, T.M.; Lopes-Ferreira, M.; Lima, C.; Ferreira, M.J.; Cunha-Junior, J.P.; Taketomi, E.A.; Goulart, L.R. & Ueira-Vieira, C. A short peptide that mimics the binding domain of TGF-β1 presents potent anti-inflammatory activity. PLoS One, 10(8): e0136116 (1-20), 2015.

  9. Yamacita-Borin, F.Y.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Fattori, V.; Alves-Filho, J.C.; Cunha, F.Q.; Cunha, T.M.; Casagrande, R.; Verri, W.A., Jr. Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice. Neurosc. Let., 605: 53-58, 2015. R46.

Prof.Dr.Wiliam Alves do Prado

  1. Mathes, C.; Melero, A.; Conrad, P.; Vogt, T.; Rigo, L.; Selzer, D.; Prado, W. A.; De Rossi, C.; Garrigues, T. M.; Hansen, S.; Guterres, S. S.; Pohlmann, A. R.; Beck, R. C.; Lehr, C. M. & Schaefer, U. F.: Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects. J Control Release. v.223 207-14.

  2. Reis, G. M.; Fais, R. S. & Prado, W. A.: The antinociceptive effect of stimulating the retrosplenial cortex in the rat tail-flick test but not in the formalin test involves the rostral anterior cingulate cortex. Pharmacol Biochem Behav. v.131 112-8.

  3. Rossaneis, A. C.; Genaro, K.; Dias, Q. M.; Guethe, L. M.; Fais, R. S.; Del Bel, E. A. & Prado, W. A.: Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats. Eur J Pain. v.19 (8): 1148-57.

  4. Rossaneis, A. C. & Prado, W. A.: The ventral portion of the anterior pretectal nucleus controls descending mechanisms that initiate neuropathic pain in rats. Clin Exp Pharmacol Physiol. v.42 (6): 704-10.

Prof. Dr. Fernando de Queiróz Cunha

  1. Barbosa, A.L.R.; Sousa, R.B.;Torres, J.N.L.; Cunha, T.M.; Cunha, F.Q.; Soares, P.M.G.; Ribeiro. R.A.; Vale, M.L. & Souza, M.H.L.P. Colitis generates remote antinociception in rats: the role of the L-arginine/NO/cGMP/PKG/KATP pathway and involvement of cannabinoid and opioid systems. Inflamm. Res., 63(12): 969-977, 2014.

  2. Barragán-Iglesias, P.; Rocha-González, H.I.; Pineda-Farias, J. B.; Murbartián, J.; Godínez-Chaparro, B.; Reinach, P.S.; Cunha, T.M.; Cunha, F.Q. & Granados-Soto, V. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. Eur. J. Pharmacol., 738: 91-100, 2014.

  3. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66(7): 1009-1020, 2014.

  4. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R.D.R.; Martins-Pinge, M.C.; Tatakihara, R.I.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr.: Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice. Physiol. & Behav., 128: 277-287, 2014.

  5. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  6. Canavaci, A.M.C.; Sorgi, C.A.; Martins, V.P.; Morais, F.R.; De Sousa, E.V.G.; Trindade, B.C.; Cunha, F.Q.; Rossi, M.A.; Aronoff, D.M.; Faccioli, L.H. & Nomizo, A. The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice. Med. Inflamm., Vol. 2014, Article ID 893634, 2014.

  7. Carmona, F.; Manso, P.H.; Silveira, V.S.; Cunha, F.Q.; De Castro, M. & Carlotti, A.P.C.P.: Inflammation, myocardial dysfunction, and mortality in children with septic shock: an observational study. Pediatr. Cardiol., 35(3): 463-470, 2014.

  8. De Aquino, S.G.; Abdollahi-Roodsaz, S.; Koenders, M.I.; Van De Loo, F.A.J.; Pruijn, G.J.M.; Marijnissen, R.J.; Walgreen, B.; Helsen, M.M.; Van Den Bersselaar, L.A.; De Molon, R.S.; Avila Campos, M.J.; Cunha, F.Q.; Cirelli, J.A. & Van Den Berg, W. B. Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response. J. Immunol., 192(9): 4103-4111, 2014.

  9. Ferreira, A.E.; Sisti, F.; Sônego, F.; Wang, S.; Filgueiras, L.R.; Brandt, S.; Serezani, A.P.M.; Du, H.; Cunha, F.Q.; Alves-Filho, J.C. & Serezani, C.H. PPAR-y/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J. Immunol., 192(5): 2357-2365, 2014.

  10. Guabiraba, R.; Besnard, A.G.; Menezes, G.B.; Secher, T.; Jabir, M.S.; Amaral, S.S.; Braun, H.; Lima-Junior, R.C.P.; Ribeiro, R.A.; Cunha, F.Q.; Teixeira, M.M.; Beyaert, R.; Graham, G.J. & Liew, F.Y. IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice. Mucosal Immunol., 7(5): 1079-1093, 2014.

  11. Gutierrez, F.R.S.; Pavanelli, W.R.; Medina, T.S.; Silva, G.K.; Mariano, F.S.; Guedes, P.M.M.; Mineo, T.W.P.; Rossi, M.A.; Cunha, F.Q. & Silva, J.S. Haeme oxygenase activity protects the host against excessive cardiac inflammation during experimental Trypanosoma cruzi infection. Microbes Infect., 16(1): 28-39, 2014.

  12. Hernandes, M.S.; D’Avila, J.C.; Trevelin, S.C.; Reis, P.A.; Kinjo, E.R.; Lopes, L.R.; Castro-Faria-Neto, H.C.; Cunha, F. Q.; Britto, L.R.G. & Bozza, F.A. The role of Nox2-derived ROS in the development of cognitive impairment after sepsis. J. Neuroinflamm., 11: 36-48, 2014.

  13. Leite, A.C.R.M.;Teotonio, M.A.A.; Girão, V.C.C.; Pompeu, M.M.L.; Nunes, R.M.; Cunha, T.M.; Pinto, A.C.M.D.; Cunha, F.Q. & Rocha, F.A.C. Meniscal transaction rather than excision increases pain behavior and structural damage in experimental osteoarthritis in mice. Osteoarth. Cartilage, 22(11):1878-1885, 2014.

  14. Lima-Junior, R.C.P.; Freitas, H.C.; Wong, D.V.T.; Wanderley, C.W.S.; Nunes, L.G.; Leite, L.L.; Miranda, S.P.; Souza, M.H.L.P.; Brito, G.A.C.; Magalhães, P.J.C.; Teixeira, M.M.; Cunha, F.Q. & Ribeiro, R.A. Targeted inhibition of IL-18 attenuates irinotecan-induced intestinal mucositis in mice. Br. J. Pharmacol., 171(9): 2335-2350, 2014.

  15. Mendonça, M.A.O.; Souto, F.O.; Micheli, D.C.; Alves-Filho, J. C.; Cunha, F.Q.; Murta, E.F.C. & Tavares-Murta, B.M. Mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy. Cancer Chemother. Pharmacol., 73(2): 317-324, 2014.

  16. Moriconi, A.; Cunha, T.M.; Souza, G.R.; Lopes, A.H.; Cunha, F.Q.; Carneiro, V. L.; Pinto, L.G.; Brandolini, L.; Aramini, A.; Bizzarri, C.; Bianchini, G.; Beccari, A.R.; Fanton, M.; Bruno, A.; Costantino, G.; Bertini, R.; Galliera, E.; Locati, M.; Ferreira, S.H.; Teixeira, M.M. & Allegretti, M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc. Natl. Acad. Sci. U S A., 111(47): 16937-16942, 2014.

  17. Prates, T.P.; Taira, T.M.; Holanda, M.C.; Bignardi, L.A.; Salvador, S.L.; Zamboni, D.S.; Cunha, F.Q. & Fukada, S.Y. NOD2 contributes to Porphyromonas gingivalis-induced bone resorption. J. Dent. Res., 93(11): 1155-1162, 2014.

  18. Sacramento, L.A.; Cunha, F.Q.; De Almeida, R.P.; Silva, J.S. & Carregaro, V. Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset. Biomed. Res. Int., Vol. 2014, Article ID 264270, 2014.

  19. Saia, R.S.; Mestriner, F.L.; Bertozi, G.; Cunha, F.Q. & Carnio, E.C. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages. Med. Inflamm., Vol. 2014: Article ID 896029, 2014.

  20. Sônego, F.; Alves-Filho, J.C. & Cunha, F.Q.: Targeting neutrophils in sepsis. Expert Rev. Clin. Immunol., 10(8): 1019-1028, 2014.

  21. Sônego, F.; Castanheira, F.V.S; Czaikoski, P.G.; Kanashiro, A.; Souto, F.O.; França, R.O.; Nascimento, D.C.; Freitas, A.; Spiller, F.; Cunha, L.D.; Zamboni, D.S.; Alves-Filho, J.C.F. & Cunha, F.Q. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS One, 9(8): e103734, 2014.

  22. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.

  23. Vieira, S.M.; Silva, R.L.; Lemos, H.P.; Amorim, R.C.N.; Silva, E.C.C.; Reinach, P.S.; Cunha, F.Q.; Pohlit, A.M. & Cunha, T. M. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, 95: 8-15, 2014.

  24. Wanderley, C.W.S.; Silva, C.M.S.; Wong, D.V.T.; Ximenes, R. M.; Morelo, D.F.C.; Cosker, F.; Aragão, K.S.; Fernandes, C.; Palheta-Junior, R.C.; Havt, A.; Brito, G.A.C.; Cunha, F.Q.; Ribeiro, R.A. & Lima-Junior, R.C.P. Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner. Toxicon, 90 134-147, 2014.

Prof. Dr. Fernando Morgan de Aguiar Corrêa

  1. Alves, F.H.F.; Crestani, C.C.; Resstel, L.B.M. & Corrêa, F.M.A. Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. PLoS One, 9(1): e83900, 2014.

  2. Busnardo, C.; Tavares, R.F. & Corrêa, F.M.A. Angiotensinergic neurotransmission in the paraventricular nucleus of the hypothalamus modulates the pressor response to acute restraint stress in rats. Neurosc., 270: 12-19, 2014.

  3. De Freitas, R.L.; De Oliveira, R.C.; De Oliveira, R.; Paschoalin-Maurin, T.; Corrêa, F.M.A. & Coimbra, N.C. The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT(2)A and 5-HT(2)C serotonergic receptors in post-ictal antinociception. Synapse, 68(1): 16-30, 2014.

  4. Fassini, A.; Scopinho, A.A.; Resstel, L.B.M. & Corrêa, F.M.A. Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat. Neuropharmacol., 85: 367-374, 2014.

  5. Moraes-Neto, T.B.; Scopinho, A.A.; Biojone, C.; Corrêa, F.M.A. & Resstel, L.B.M. Involvement of dorsal hippocampus glutamatergic and nitrergic neurotransmission in autonomic responses evoked by acute restraint stress in rats. Neuroscience, 258: 364-373, 2014.

  6. Reis, D.G.; Fortaleza, E.A.T.; Tavares, R.F. & Corrêa, F.M.A. Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats. Stress, 17(4): 362-372, 2014.

  7. Terzian, A.L.B.; Reis, D.G.; Guimarães, F.S.; Corrêa, F.M.A. & Resstel, L.B.M. Medial prefrontal cortex Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats. Psychopharmacol. (Berl), 231(1): 149-157, 2014.

  8. Crestani, C.C.; Silva, A.L.; Scopinho, A.A.; Ruginsk, S.G.; Uchoa, E.T.; Corrêa, F.M.A.; Elias, L.L.K.; Antunes-Rodrigues, J. & Resstel, L.B.M. Cardiovascular alterations at different stages of hypertension development during ethanol consumption: Time-course of vascular and autonomic changes. Toxicol. Appl. Pharmacol., 280(2): 245-255, 2014.

  9. Fabri, D.R.S.; Hott, S.C.; Reis, D.G.; Biojone, C.; Corrêa, F.M.A. & Resstel, L.B.M. The expression of contextual fear conditioning involves activation of a NMDA receptor-nitric oxide-cGMP pathway in the dorsal hippocampus of rats. Eur. Neuropsychopharmacol., 24(10): 1676-1686, 2014.

Prof. Dr. Francisco Silveira Guimarães

  1. Aguiar, D.C.; Hott, S.C.; Deolindo, M.V.; Guimarães, F.S. & Resstel, L.B.M. The dorsolateral periaqueductal grey N-methyl-D-aspartate/nitric oxide/cyclic guanosine monophosphate pathway modulates the expression of contextual fear conditioning in rats. J. Psychopharmacol., 28(5): 479-485,2014.

  2. Aguiar, D.C.; Moreira, F.A.; Terzian, A.L.; Fogaça, M.V.; Lisboa, S.F.; Wotjak, C.T. & Guimarães, F.S. Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels. Neurosci. Biobehav. Rev., 46(3): 418-428, 2014.

  3. Batalla, A.; Crippa, J.A.; Busatto, G.F.; Guimarães, F.S.; Zuardi, A.W.; Valverde, O.; Atakan, Z.; McGuire, P.K.; Bhattacharyya, S. & Martin-Santos, R. Neuroimaging of acute of THC and CBD in humans and animals: a systematic review. Curr. Pharm. Des., 20(13): 2168-2185, 2014.

  4. Del-Bel, E.; Padovan-Neto, F.E.; Szawka, R.E.; Da-Silva, C. A.; Raisman-Vozari, R.; Anselmo-Franci, J.; Romano-Dutra, A. C. & Guimarães, F.S. Counteraction by nitric oxide synthase inhibitor of neurochemical alterations of dopaminergic system in 6-OHDA-lesioned rats under ʟ-DOPA treatment. Neurotox Res., 25(1): 33-44, 2014.

  5. Fogaça, M.V.; Reis, F.M.C.V.; Campos, A.C. & Guimarães, F. S. Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience. Eur. Neuropsychopharmacol., 24(3): 410-419, 2014.

  6. Gomes, F.V.; Kakihata, A.M.; Semedo, A.C.G.; Hott, S.C.; Uliana, D.L.; Guimarães, F.S. & Resstel, L.B.M. D-cycloserine injected into the dorsolateral periaqueductal gray induces anxiolytic-like effects in rats. Behav. Brain Res., 271: 374-379, 2014.

  7. Lisboa, S.F.; Camargo, L.H.A.; Magesto, A.C.; Resstel, L.B.M. & Guimarães, F.S. Cannabinoid modulation of predator fear: involvement of the dorsolateral periaqueductal gray. Int. J. Neuropsychopharmacol., 17(8): 1193-1206, 2014.

  8. Nardo, M.; Casarotto, P.C.; Gomes, F.V. & Guimarães, F.S. Cannabidiol reverses the mCPP-induced increase in marble-burying behavior. Fundam. Clin. Pharmacol., 28(5): 544-550, 2014.

  9. Schiavon, A.P.; Soares, L.M.; Bonato, J.M.; Milani, H.; Guimarães, F.S. & Oliveira, R.M.W. Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice. Neurotox. Res., 26(4): 307-316, 2014.

  10. Silveira, J.W.; Issy, A.C.; Castania, V.A.; Salmon, C.E.G.; Nogueira-Barbosa, M.H.; Guimarães, F.S.; Defino, H.L.A. & Del Bel, E. Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. PLoS One, 9(12): e113161, 2014.

  11. Terzian, A.L.B.; Reis, D.G.; Guimarães, F.S.; Corrêa, F.M.A. & Resstel, L.B.M. Medial prefrontal cortex Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats. Psychopharmacol. (Berl), 231(1): 149-157, 2014.

Prof. Dr. José Carlos Farias Alves Filho

  1. Barbour, M.; Allan, D.; Xu, H.; Pei, C.; Chen, M.; Niedbala, W.; Fukada, S.Y.; Besnard, A-G.; Alves-Filho, J.C.; Tong, X.; Forrester, J.V.; Liew, F.Y. & Jiang, H-R. IL-33 attenuates the development of experimental autoimmune uveitis. Eur. J. Pharmacol., 44(11): 3320-3329, 2014.

  2. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66(7): 1009-1020, 2014.

  3. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  4. Ferreira, A.E.; Sisti, F.; Sônego, F.; Wang, S.; Filgueiras, L.R.; Brandt, S.; Serezani, A.P.M.; Du, H.; Cunha, F.Q.; Alves-Filho, J.C. & Serezani, C.H. PPAR-y/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J. Immunol., 192(5): 2357-2365, 2014.

  5. Mendonça, M.A.O.; Souto, F.O.; Micheli, D.C.; Alves-Filho, J. C.; Cunha, F.Q.; Murta, E.F.C. & Tavares-Murta, B.M. Mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy. Cancer Chemother. Pharmacol., 73(2): 317-324, 2014.

  6. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.

  7. Sônego, F.; Alves-Filho, J.C. & Cunha, F.Q.: Targeting neutrophils in sepsis. Expert Rev. Clin. Immunol., 10(8): 1019-1028, 2014.

  8. Sônego, F.; Castanheira, F.V.S; Czaikoski, P.G.; Kanashiro, A.; Souto, F.O.; França, R.O.; Nascimento, D.C.; Freitas, A.; Spiller, F.; Cunha, L.D.; Zamboni, D.S.; Alves-Filho, J.C.F. & Cunha, F.Q. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS One, 9(8): e103734, 2014.

Prof. Dr. José Eduardo Tanus dos Santos

  1. Antonio, R.C.; Ceron, C.S.; Rizzi, E.; Coelho, E. B.; Tanus-Santos, J.E. & Gerlach, R.F. Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR. Mol. Cell. Biochem., 386(1-2): 99-105, 2014.

  2. Castro, M.M. & Tanus-Santos, J.E. Targeting matrix metalloproteinases in disease conditions. Acupunct. Med., 32(5): 373-375, 2014.

  3. Eleutério, N.M.; Palei, A.C.T.; Machado, J.S.R.; Tanus-Santos, J.E.; Cavalli, R.C. & Sandrim, V.C. Correlations between circulating levels of adipokines and anti-angiogenic factors in women with BMI <30 and a late-onset preeclampsia. Hypertens. Pregnancy, 33(1): 72-80, 2014.

  4. Fontana, V.; De Faria, A.P.C.; Oliveira-Paula, G.H.; Silva, P. S.; Biagi, C.; Tanus-Santos, J.E. & Moreno, H. Effects of angiotensin-converting enzyme inhibition on leptin and adiponectin levels in essential hypertension. Basic & Clin. Pharmacol. Toxicol., 114(6): 472-475, 2014.

  5. Lacchini, R.; Luizon, M.R.; Gasparini, S.; Ferreira-Sae, M.C.; Schreiber, R.; Nadruz, W., Jr. & Tanus-Santos, J.E. Effect of genetic polymorphisms of vascular endothelial growth factor on left ventricular hypertrophy in patients with systemic hypertension. Am. J. Cardiol., 113(3): 491-496, 2014.

  6. Lacchini, R.; Muniz, J.J.; Nobre, Y.T.D.A.; Cologna, A.J.; Martins, A.C.P. & Tanus-Santos, J.E. nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction. Pharmacogenomics, 15(6): 775-784, 2014.

  7. Lacchini, R. & Tanus-Santos, J.E. Pharmacogenetics of erectile dysfunction: navigating into uncharted waters. Pharmacogenomics, 15(11): 1519-1538, 2014.

  8. Luizon, M.R.; Palei, A.C.T.; Sandrim, V.C.; Amaral, L.M.; Machado, J.S.R.; Lacchini, R.; Cavalli, R.C.; Duarte, G. & Tanus-Santos, J.E. Tissue inhibitor of matrix metalloproteinase-1 polymorphism, plasma TIMP-1 levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy. The Pharmacogenomics J., 14(6): 535-541, 2014.

  9. Machado, J.S.R.; Palei, A.C.T.; Amaral, L.M.; Bueno, A.C.; Antonini, S.R.; Duarte, G.; Tanus-Santos, J.E.; Sandrim, V. C. & Cavalli, R.C. Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia. J. Human Hypertens., 28(2): 128-132, 2014.

  10. Montenegro, M.F.; Pinheiro, L.C.; Amaral, J.H.; Ferreira, G. C.; Portella, R.L. & Tanus-Santos, J.E. Vascular xanthine oxidoreductase contributes to the antihypertensive effects of sodium nitrite in ʟ-NAME hypertension. Naunyn- Schmiedeberg´s Arch. Pharmacol., 387(6): 591-598, 2014.

  11. Oliveira-Paula, G.H.; Lacchini, R. & Tanus-Santos, J.E. Inducible nitric oxide synthase as a possible target in hypertension. Curr. Drug Targets, 15(2): 164-174, 2014.

  12. Pinheiro, L.C.; Amaral, J.H.; Ferreira, G.C.; Montenegro, M.F.; Oliveira-Paula, G.H. & Tanus-Santos, J.E. The antihypertensive effects of sodium nitrite are not associated with circulating angiotensin converting enzyme inhibition. Nitric Oxide, 40: 52-59, 2014.

  13. Rezende, V.B.; Barbosa, F., Jr.; Palei, A.C.; Cavalli, R.C.; Tanus-Santos, J.E. & Sandrim, V.C. Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy. J. Trace Elem. Med. Biol., 29: 130-135, 2014.

  14. Rizzi, E.; Guimarães, D.A.; Ceron, C.S.; Prado, C.M.; Pinheiro, L.C.; Martins-Oliveira, A.; Gerlach, R.F. & Tanus-Santos, J. E. β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free Radic. Biol. Med., 73: 308-317, 2014.

  15. Silva, R.F.; Sertório, J.T.C.; Lacchini, R.; Trapé, A.A.; Tanus-Santos, J.E.; Rush, J.W.E.; Amaral, S.L. & Zago, A.S. Influence of training status and eNOS haplotypes on plasma nitrite concentrations in normotensive older adults: a hypothesis-generating study. Aging Clin. Exp. Res., 26(6): 591-598, 2014.

  16. Villela, M.P.; Andrade, V.L.; Eccard, B.; Jordão, A.A.; Sertório, J.T.; Tanus-Santos, J.E.; Silva, I.F.; Silveira, J.N. & Sandrim, V.C. Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin. Clin. Exp. Pharmacol. Physiol., 41(10): 744-747, 2014.

  17. Windsant, I.C.V.; De Wit, N.C.J.; Sertorio, J.T.C.; Van Bijnen, A.A.; Ganushchak, Y.M.; Heijmans, J.H.; Tanus-Santos, J.E.; Jacobs, M.J.; Maessen, J.G. & Buurman, W.A. Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Frontiers Physiol., 5: Article 340(1-9), 2014.

  18. Zago, V.H.S.; Tanus-Santos, J.E.; Danelon, M.R.G.; Parra, E.S.; Alexandre, F.; Vieira, I.C.; Panzoldo, N.B.; D´Alexandri, F.L.; Quintão, E.C.R. & Faria, E.C. Chemical modification of high density lipoprotein subfractions – HDL2 and HDL3 – after use of atorvastatin. Int. J. Clin. Pharmacol. Ther., 52(4): 277-283, 2014.

Prof. Dr. Norberto Cysne Coimbra

  1. De Freitas, R.L.; De Oliveira, R.C.; De Oliveira, R.; Paschoalin-Maurin, T.; Corrêa, F.M.A. & Coimbra, N.C. The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT(2)A and 5-HT(2)C serotonergic receptors in post-ictal antinociception. Synapse, 68(1): 16-30, 2014.

  2. De Freitas, R.L.; Salgado-Rohner, C.J.; Biagioni, A.F.; Medeiros, P.; Hallak, J.E.C.; Crippa, J.A.S. & Coimbra, N.C. NMDA and AMPA/kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus. Cereb. Cortex, 24(6): 1518-1528, 2014.

  3. Gonçalves, T.C.T.; Londe, A.K.; Albano, R.I.P.; Araújo Junior, A.T.; Azeredo, M.A.; Biagioni, A.F.; Vasconcellos, T.H.F.; Ferreira, C.M.R.; Teixeira, D.G.; Crippa, J.A.S.; Vieira, D. & Coimbra, N.C. Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system. J. Neurol. Sci., 347(1-2): 82-89, 2014.

  4. Linares, I.M.P.; Jackowski, A.P.; Trzesniak, C.M.F.; Arrais, K.C.; Chagas, M.H.N.; Sato, J.R.; Santos, A.C.; Hallak, J.E.C.; Zuardi, A.W.; Nardi, A.E.; Coimbra, N.C. & Crippa, J.A.S. Cortical thinning of the right anterior cingulate cortex in spider phobia: A magnetic resonance imaging and spectroscopy study. Brain Res., 1576: 35-42, 2014.

  5. Mazzei-Silva, E.C.; De Oliveira, R.C.; Dos Anjos Garcia, T.; Falconi-Sobrinho, L.L.; Almada, R.C. & Coimbra, N.C. Intrinsic connections within the pedunculopontine tegmental nucleus are critical to the elaboration of post-ictal antinociception. Synapse, 68(8): 369-377,2014.

Profa. Dra. Rita de Cássia Aleixo Tostes Passaglia

  1. Bruder-Nascimento, T.; Chinnasamy, P.; Riascos-Bernal, D. F.; Cau, S.B.; Callera, G.E.; Touyz, R.M.; Tostes, R.C. & Sibinga, N.E.S. Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. J. Mol. Cell Cardiol., 66: 18-26, 2014.

  2. Bruder-Nascimento, T.; Silva, M.A.B. & Tostes, R.C. The involvement of aldosterone on vascular insulin resistance: implications in obesity and type 2 diabetes. Diabetol. & Metab. Syndr., 6(1): 90-98, 2014.

  3. Ceravolo, G.S.; Montezano, A.C.; Jordão, M.T.; Akamine, E. H.; Costa, T.J.; Takano, A.P.; Fernandes, D.C.; Barreto-Chaves, M.L.; Laurindo, F.R.; Tostes, R.C.; Fortes, Z.B.; Chopard, R.P.; Touyz, R.M. & Carvalho, M.H.C. An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: In vivo and In vitro studies. PLoS One, 9(11): e111117, 2014.

  4. Giachini, F.R.; Leite, R.; Osmond, D.A.; Lima, V.V.; Inscho, E. W.; Webb, R.C. & Tostes, R.C. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats. PLoS One, 9(3): e91890, 2014.

  5. Lima, V.V.; Lobato, N.S.; Filgueira, F.P.; Webb, R.C.; Tostes, R.C. & Giachini, F.R. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain. Braz. J. Med. Biol. Res., 47(10): 826-833, 2014.

  6. Lopes, R.A.M.; Neves, K.B.; Pestana, C.R.; Queiroz, A.L.; Zanotto, C.Z.; Chignalia, A.Z.; Valim, Y.M.; Silveira, L.R.; Curti, C. & Tostes, R.C. Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. Am. J. Physiol. Heart Circ. Physiol., 306(11): H1485-H1494, 2014.

  7. Matsumoto, T.; Lopes, R.A.M.; Taguchi, K.; Kobayashi, T. & Tostes, R.C. Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sci., 118(2): 129-135, 2014.

  8. Neves, K.B.; Lobato, N.S.; Lopes, R.A.M.; Filgueira, F.P.; Zanotto, C.Z.; De Oliveira, A.M. & Tostes, R.C. Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity? Clin. Sci. (Lond), 127 (2): 111-122, 2014.

  9. Santos, P.P.; Rafacho, B.P.M.; Gonçalves A.F.; Jaldin, R.G.; Bruder-Nascimento, T.; Silva, M.A.B.; Cau, S.B.A.; Roscani, M.G.; Azevedo, P.S.; Minicucci, M.F.; Tostes R.C.; Zornoff, L. A.M. & Paiva, S.A.R. Vitamin D induces increased systolic arterial pressure via vascular reactivity and mechanical properties. PLoS One, 9(6): e98895, 2014.

Prof. Dr. Thiago Mattar Cunha

  1. Aguiar, C.J.; Rocha-Franco, J.A.; Sousa, P.A.; Santos, A.K.; Ladeira, M.; Rocha-Resende, C.; Ladeira, L.O.; Resende, R.R.; Botoni, F.A.; Melo, M.B.; Lima, C.X.; Carballido, J.M.; Cunha, T.M.; Menezes, G.B.; Guatinosim, S. & Leite, M.F. Succinate causes pathological cardiomyocyte hypertrophy througfh GPR91 activation. Cell. Communic. & Signal., 12(1): 78-94, 2014.

  2. Barbosa, A.L.R.; Sousa, R.B.;Torres, J.N.L.; Cunha, T.M.; Cunha, F.Q.; Soares, P.M.G.; Ribeiro. R.A.; Vale, M.L. & Souza, M.H.L.P. Colitis generates remote antinociception in rats: the role of the L-arginine/NO/cGMP/PKG/KATP pathway and involvement of cannabinoid and opioid systems. Inflamm. Res., 63(12): 969-977, 2014.

  3. Barragán-Iglesias, P.; Rocha-González, H.I.; Pineda-Farias, J. B.; Murbartián, J.; Godínez-Chaparro, B.; Reinach, P.S.; Cunha, T.M.; Cunha, F.Q. & Granados-Soto, V. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. Eur. J. Pharmacol., 738: 91-100, 2014.

  4. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66 (7): 1009-1020, 2014.

  5. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R.D.R.; Martins-Pinge, M.C.; Tatakihara, R.I.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr.: Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice. Physiol. & Behav., 128: 277-287, 2014.

  6. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  7. Figueiredo, S.A.; Vilela, F.M.P.; Silva, C.A.; Cunha, T.M.; Santos, M.H. & Fonseca, M.J.V. In vitro and in vivo photoprotective/photochemopreventive potential of Garcinia brasiliensis epicarp extract. J. Photochem. Photobiol. B: Biol., 131: 65-73. 2014.

  8. Ivan, A.L.M.; Campanini, M.Z.; Martinez, R.M.; Ferreira, V.S.; Steffen, V.S.; Vicentini, F.T.M.C.; Vilela, F.M.P.; Martins, F.S.; Zarpelon, A.C.; Cunha, T.M.; Fonseca, M.J.V.; Baracat, M.M.; Georgetti, S.R. & Verri, W.A., Jr. Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro. J. Photochem. Photobiol. B: Biol. 138: 124-133, 2014.

  9. Leite, A.C.R.M.;Teotonio, M.A.A.; Girão, V.C.C.; Pompeu, M.M.L.; Nunes, R.M.; Cunha, T.M.; Pinto, A.C.M.D.; Cunha, F.Q. & Rocha, F.A.C. Meniscal transaction rather than excision increases pain behavior and structural damage in experimental osteoarthritis in mice. Osteoarth. Cartilage, 22(11):1878-1885, 2014.

  10. Moriconi, A.; Cunha, T.M.; Souza, G.R.; Lopes, A.H.; Cunha, F.Q.; Carneiro, V. L.; Pinto, L.G.; Brandolini, L.; Aramini, A.; Bizzarri, C.; Bianchini, G.; Beccari, A.R.; Fanton, M.; Bruno, A.; Costantino, G.; Bertini, R.; Galliera, E.; Locati, M.; Ferreira, S.H.; Teixeira, M.M. & Allegretti, M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc. Natl. Acad. Sci. U S A., 111(47): 16937-16942, 2014.

  11. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.

  12. Vieira, S.M.; Silva, R.L.; Lemos, H.P.; Amorim, R.C.N.; Silva, E.C.C.; Reinach, P.S.; Cunha, F.Q.; Pohlit, A.M. & Cunha, T. M. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, 95: 8-15, 2014.

Prof. Dr. Sérgio Henrique Ferreira

  1. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66 (7): 1009-1020, 2014.

  2. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R.D.R.; Martins-Pinge, M.C.; Tatakihara, R.I.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr.: Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice. Physiol. & Behav., 128: 277-287, 2014.

  3. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  4. Ferrari, L.F.; Lotufo, C.M.; Araldi, D.; Rodrigues, M.A.; Macedo L.P.; Ferreira, S.H. & Parada, C.A. Inflammatory sensitization of nociceptors dependes on activation of NMDA receptors in DRG satellite cells. Proc. Natl. Acad. Sci. U S A., 111(51): 18363-18368, 2014.

  5. Garrido-Suárez, B.B.; Garrido, G.; Castro-Labrada, M.; Merino, N.; Valdés, O.; Rodeiro, I.; Hernandez, I.; Godoy-Figueiredo, J.; Ferreira, S.H. & Delgado-Hernández, R. Anti-hypernociceptive effect of mangiferin in persistent and neuropathic pain models in rats. Pharmacol. Biochem. Behav., 124: 311-319, 2014.

  6. Malvar, D.C.; Aguiar, F.A.; Vaz, A.L.L.; Assis, D.C.R.; Melo, M.C.C.; Jabor, V.A.P.; Kalapothakis, E.; Ferreira, S.H.; Clososki, C. & Souza, G.E.P. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2-dependent and –independent fever while 4-AA only blocks PGE2-dependent fever. Brit. Pharmacol. Soc.; 171(5): 3666-3679, 2014.

  7. Moriconi, A.; Cunha, T.M.; Souza, G.R.; Lopes, A.H.; Cunha, F.Q.; Carneiro, V. L.; Pinto, L.G.; Brandolini, L.; Aramini, A.; Bizzarri, C.; Bianchini, G.; Beccari, A.R.; Fanton, M.; Bruno, A.; Costantino, G.; Bertini, R.; Galliera, E.; Locati, M.; Ferreira, S.H.; Teixeira, M.M. & Allegretti, M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc. Natl. Acad. Sci. U S A., 111(47): 16937-16942, 2014.

  8. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.

Prof. Dr. Fernando de Queiróz Cunha

  1. Barroso-Sousa, R.; Lobo, R.R.; Mendonça, P.R.; Memória, R.R.; Spiller, F.; Cunha, F.Q. & Pazin-Filho, A. Decreased levels of alpha-1-acid glycoprotein are related to the mortality of septic patients in the emergency department. Clinics (São Paulo), 68(8): 1134-1139, 2013.

  2. Cangussú, S.D.; Souza, C.C.; Castro, M.S.A.; Vieira, L.Q.; Cunha, F.Q.; Afonso, L.C.C. & Arantes, R.M.E. The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania major-induced lesions related to nociceptive thresholds. Exp. Parasitol., 133(2): 193-200, 2013.

  3. Carlos, D.; Spiller, F.; Souto, F.O. Trevelin, S.C.; Borges, V.F.; de Freitas, A.; Alves-Filho, J.C.; Silva, J.S.; Ryffel, B. & Cunha, F.Q. Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model. J. Immunol., 191(3): 1373-1382, 2013.

  4. Carregaro, V.; Costa, D.L.; Brodskyn, C.; Barral, A.M.; Barral-Netto, M.; Cunha, F.Q. & Silva, J.S. Dual effect of Lutzomyia longipalpis saliva on Leishmania braziliensis infection is mediated by distinct salina-induced cellular recruitment into BALB/c mice ear. BMC Microbiol., 13:102, 2013.

  5. Carreira, E.U.; Carregaro, V.; Teixeira, M.M.; Moriconi, A.; Aramini, A.; Verri Jr., W.A.; Ferreira, S.H.; Cunha, F.Q. & Cunha, T.M. Neutrophils recruited by CXCR1/2 signalling mediate post-incisional pain. Eur. J. Pain, 17(5): 654-663, 2013.

  6. Czaikoski, P.G.; Nascimento, D.C.; Sônego, F.; de Freitas, A.; Turato, W.M.; de Carvalho, M.A.; Santos, R.S.; de Oliveira, G.P.; dos Santos Samary, C.; Tefé-Silva, C.; Alves-Filho, J.C.; Ferreira, S.H.; Rossi, M.A.; Rocco, P.R.; Spiller, F. & Cunha, F.Q. Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis. Shock, 39(4): 389-396, 2013.

  7. De Luca, B.; Xavier-Elsas, P.; Barradas, M.; Luz, R. A.; Queto, T.; Jones, C.; Arruda, M. A.; Cunha, T. M.; Cunha, F. Q. & Gaspar-Elsas, M. I. Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents. Scientific World Journal., 2013, 208705 (Electronic).

  8. Donate, P.B.; Fornari, T.A.; Macedo, C.; Cunha, T.M.; Nascimento, D.C.B.; Sakamoto-Hojo, E.T.; Donadi, E.A.; Cunha, F.Q. & Passos, G.A. T cell post-transcriptional Mirna-mRNA interaction networks identify targets associated with susceptibility/resistance to collagen-induced arthritis. PloS ONE, 8(1): e54803, 2013.

  9. Figueiredo, J.; Ferreira, A.E.; Silva, R.L.; Ulloa, L.; Grieco, P.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q. & Kanashiro, A. NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. Naunyn-Schmiedeberg´s Arch. Pharmacol., 386(4): 311-318, 2013.

  10. Godoi, D. F.; Cardoso, C. R.; Silva, M. J.; Ferraz, D. B.; Provinciatto, P. R.; Cunha Fde, Q.; Da Silva, J. S. & Voltarelli, J. C.: Reappraisal of total body irradiation followed by bone marrow transplantation as a therapy for inflammatory bowel disease. Immunobiol., 218(3): 317-324, 2013.

  11. Guerrero, A.T.; Zaperlon, A.C.; Vieira, S.M.; Pinto, L.G.; Ferreira, S.H.; Cunha, F.Q.; Verri Jr., W.A.; & Cunha, T.M. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. Naunyn-Schmiedeberg´s Arch. Pharmacol., 386(1): 51-59, 2013.

  12. Hohmann, M. S.; Cardoso, R. D.; Pinho-Ribeiro, F. A.; Crespigio, J.; Cunha, T. M.; Alves-Filho, J. C.; Da Silva, R. V.; Pinge-Filho, P.; Ferreira, S. H.; Cunha, F. Q.; Casagrande, R. & Verri, W. A., Jr.: 5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality. Biomed. Res. Int., 2013 627046. (Electronic).

  13. Magro, D.A.C.; Hohmann, M.S.N.; Mizokami, S.S.; Cunha, T.M.; Alves-Filho, J.C.; Casagrande, R.; Ferreira, S.H.; Liew, F.Y.; Cunha, F.Q. & Verri Jr, W.A. An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice. Braz. J. Med. Biol. Res., 46(7): 601-606, 2013.

  14. Petinatti Pavarini, D.; Nogueira, E. F.; Callejon, D. R.; Soares, D. M.; De Souza, G. E.; Cunha Fde, Q.; Lopes, J. L. & Lopes, N. P.: Novel bisabolane derivative from “arnica-da-serra” (Vernonieae: Asteraceae) reduces pro-nociceptive cytokines levels in LPS-stimulated rat macrophages. J. Ethnopharmacol., 148(3): 993-998, 2013.

  15. Pinto, A. C.; Cordeiro Rde, A.; Sidrim, J. J.; Leite, A. K.; Leite, A. C.; Girao, V. C.; Brilhante, R. S.; Rocha, M. F.; Cunha Fde, Q. & Rocha, F. A.: Anti-inflammatory and immunomodulatory effect of an extract of Coccidioides posadasii in experimental arthritis. Mycopathologia, 175(3-4): 193-206, 2013.

  16. Polli-Lopes, A.C.; Estofolete, C.F.; Oliani, S.M.; Zucoloto, S.; Cunha, F.Q. & Gil, C.D. Myenteric denervation in gastric carcinogenesis: differential modujlation of nitric oxide and annexin-A1. Int. J. Clin. Exp. Pathol., 6(1): 13-23, 2013.

  17. Saia, R.S.; Bertozi, G.; Mestriner, F.L.; Antunes-Rodrigues, J.; Queiroz Cunha, F.; Cárnio, E.C. Cardiovascular and infflammatory response to cholecystokinin during endotoxemic shock. Shock, 39(1): 1004-1013, 2013.

  18. Soares, P.M.G.; Mota, J.M.S.C.; Souza, E.P.; Justino, P.F.C.; Franco, A.X.; Cunha, F.Q.; Ribeiro, R.A. & Souza, M.H.L.P. Inflammatory intestinal damage induced by 5-fluorouracil requires IL-4. Cytokine, 61(1): 46-49, 2013.

  19. Souza, G.R.; Talbot, J.; Lotufo, C.M.; Cunha, F.Q.; Cunha, T.M. & Ferreira, S.H. Fractalkine mediates inflammatory pain through activation of satellite glial cells. Proc. Natl. Acad. Sci. USA., 110(27): 11193-11198, 2013.

  20. Tristão, F.S.M.; Rocha, F.A.; Moreira, A.P.; Cunha, F.Q.; Rossi, M.A. & Silva, J.S. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infection and Immunity, 81(4): 1256-1266, 2013.

  21. Vercelino, R.; Cunha, T.M.; Ferreira, E.S.; Cunha, F.Q.; Ferreira, S.H. & Oliveira, M.G. Skin vasodilation and analgesic effect of a topical nitric oxide-releasing hydrogel. J. Mater Sci: Mater Med., 24(9): 2157-2169, 2013.

  22. Villarreal, C. F.; Funez, M. I.; Cunha Fde, Q.; Parada, C. A. & Ferreira, S. H. The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice. Pharmacol. Biochem. Behav., 103(3): 678-683, 2013.

  23. Yaochite, J.N.U.; Caliari-Oliveira, C.; Davanso, M.R.; Carlos, D.; Malmegrim, K.C.R.; Cardoso, C.R.B.; Ramalho, L.N.Z.; Palma, P.V.B.; Silva, J.S.; Cunha, F.Q.; Covas, D.T. & Voltarelli, J.C. Dynamic changes of the Th17/Tc17 and regulatory T cell populations interfere in the experimental autoimmune diabetes pathogenesis. Immunobiol., 218(3): 338-352, 2013.

  24. Zarpelon, A. C.; Cunha, T. M.; Alves-Filho, J. C.; Pinto, L. G.; Ferreira, S. H.; Mcinnes, I. B.; Xu, D.; Liew, F. Y.; Cunha, F. Q. & Verri, W. A., Jr. IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2. Br. J. Pharmacol., 169(1): 90-101, 2013.

  25. Zarpelon, A.C.; Souza, G.R.; Cunha, T.M.; Schivo, I.R.S.; Marchesi, M.; Casagrande, R.; Pinge-Filho, P.; Cunha, F.Q.; Ferreira, S.H.; Miranda, K.M. & Verri Jr., W.A. The nitroxyl donor, Angeli´s salt, inhibits inflammatory hyperalgesia in rats. Neuropharmacol., 71: 1-9, 2013.

Prof. Dr. Fernando Morgan de Aguiar Corrêa

  1. Alves, F.H.F.; Gomes, F.V.; Reis, D.G.; Crestani, C.C.; Corrêa, F.M.A.; Guimarães, F.S. & Resstel, L.B.M. Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning. Eur. J. Neurosci., 38(2): 2300-2307, 2013.

  2. Busnardo, C.; Alves, F.H.F.; Crestani, C.C.; Scopinho, A.A.; Resstel, L.B.M. & Corrêa, F. M. A. Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats. Eur. Neuropsychopharmacol., 23(11): 1611-1622, 2013.

  3. Busnardo, C.; Ferreira-Junior, N.C.; Cruz, J.C.; Machado, B.H.; Corrêa, F.M.A. & Resstel, L.B.M. Cardiovascular responses to ATP microinjected into the paraventricular nucleus are mediated by nitric oxide and NMDA glutamate receptors in awake rats. Exp. Physiol., 98(10): 1411-1421, 2013.

  4. Camargo, L.H.A.; Alves, F.H.F.; Biojone, C.; Corrêa, F.M.A.; Resstel, L.B.M. & Crestani, C.C. Involvement of N-methyl-D-aspartate glutamate receptor and nitric oxide in cardiovascular responses to dynamic exercise in rats. Eur. J. Pharmacol., 713(1-3): 16-24, 2013.

  5. Crestani, C.C.; Alves, F.H.F.; Gomes, F.V.; Resstel, L.B.M.; Corrêa, F.M.A. & Herman, J.P. Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: a review. Curr. Neuropharmacol., 11(2): 141-159, 2013.

  6. Da Silva, A.L.; Ruginsk, S.G.; Uchoa, E.T.; Crestani, C.C.; Scopinho, A.A.; Corrêa, F.M.A.; De Martinis, B.S.; Elias, L.L.K.; Resstel, L.B.M. & Antunes-Rodrigues, J. Time-course of neuroendocrine changes and its correlation with hypertension induced by ethanol consumption. Alcohol Alcohol., 48(4): 495-504, 2013.

  7. De Freitas, R.L.; Bolognesi, L.I.; Twardowschy, A.; Corrêa, F.M.A.; Sibson, N. R. & Coimbra, N.C. Neuroanatomical and neuropharmacological approaches to postictal antinociception-related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors. Brain Behav., 3(3): 286-301, 2013.

  8. Deolindo, M.V.; Reis, D.G.; Crestani, C.C.; Tavares, R.F.; Resstel, L.B.M. & Corrêa, F.M.A. NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats. Eur. J. Neurosci., 38(3): 2374-2381, 2013.

  9. Gomes, F.V.; Alves, F.H.F.; Guimarães, F.S.; Corrêa, F.M.A.; Resstel, L.B.M. & Crestani, C.C. Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor. Eur. Neuropsychopharmacol., 23(9): 1096-1104, 2013.

  10. Guethe, L.M.; Pelegrini-da-Silva, A.; Borelli, K.G.; Juliano, M.A.; Pelosi, G.G.; Pesquero, J.B.; Silva, C.L.M.; Corrêa, F.M.A.; Murad, F.; Prado, W.A. & Martins, A.R. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience, 231: 315-327, 2013.

  11. Lopes-Azevedo, S.; Busnardo, C. & Corrêa, F.M.A. Mechanism of the cardiovascular response caused by L-proline microinjected into the supraoptic nucleus of the hypothalamus in unanesthetized rats. Amino Acids, 45(4): 797-810, 2013.

  12. Pernomian, L.; Gomes, M.S.; Corrêa, F.M.A.; Restini, C.B.A.; Ramalho, L.N.Z. & De Oliveira, A. M. Diabetes confers a vasoprotective role to the neurocompensatory response elicited by carotid balloon injury: consequences on contralateral carotid tone and blood flow. Eur. J. Pharmacol., 708(1-3): 124-138, 2013.

  13. Santini, C.O.; Fassini, A.; Scopinho, A.A.; Busnardo, C.; Corrêa, F.M.A. & Resstel, L.B.M. The ventral hippocampus NMDA receptor/nitric oxide/guanylate cyclase pathway modulates cardiovascular responses in rats. Auton. Neurosci.: Basic & Clin., 177(2): 244-252, 2013.

  14. Scopinho, A.A.; Lisboa, S.F.S.; Guimarães, F.S.; Corrêa, F.M.A.; Resstel, L.B.M. & Joca, S.R.L. Dorsal and ventral hippocampus modulate autonomic responses but not behavioral consequences associated to acute restraint stress in rats. PLoS One, 8(10): e77750, 10 pages, 2013.

Prof. Dr. Francisco Silveira Guimarães

  1. Aguiar, D.C.; Hott, S.C.; Deolindo, M.V.; Guimarães, F.S. & Resstel, L.B.M. The dorsolateral periaqueductal grey N-methyl-D-aspartate/nitric oxide/cyclic guanosine monophosphate pathway modulates the expression of contextual fear conditioning in rats. J. Psychopharmacol., 2013, in press.

  2. Almeida-Santos, A.F.; Gobira, P.H.; Rosa, L.C.; Guimarães, F.S.; Moreira, F.A. & Aguiar, D.C. Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. Behav. Brain Res., 252: 10-17, 2013.

  3. Almeida-Santos, A.F.; Moreira, F.A.; Guimarães, F.S. & Aguiar, D.C. Role of TRPV1 receptors on panic-like behaviors mediated by the dorsolateral periaqueductal gray in rats. Pharmacol. Biochem. Behav., 105: 166-172, 2013.

  4. Alves, F.H.F.; Gomes, F.V.; Reis, D.G.; Crestani, C.C.; Corrêa, F.M.A.; Guimarães, F.S. & Resstel, L.B.M. Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning. Eur. J. Neurosci., 38(2): 2300-2307, 2013.

  5. Batalla, A.; Crippa, J.A.; Busatto, G.F.; Guimarães, F.S.; Zuardi, A.W.; Valverde, O.; Atakan, Z.; McGuire, P.K.; Bhattacharyya, S.; Martin-Santos, R. Neuroimaging studies of acute effects of THC and CBD in humans and animals: A systematic review. Curr. Pharm. Dês., 2013, in press.

  6. Campos, A.C.; Soares, V.P.; Carvalho, M.C.; Ferreira, F.R.; Vicente, M.A.; Brandão, M.L.; Zuardi, A.W.; Zangrossi, H., Jr. & Guimarães, F.S. Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. Psychopharmacol., 226(1): 13-24, 2013.

  7. Campos, A.C.; Ferreira, F.R.; Da Silva, W. A., Jr. & Guimarães, F.S. Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms. Neurosci. Lett., 533: 34-38, 2013.

  8. Campos, A.C.; Fogaça, M.V.; Aguiar, D.C. & Guimarães, F.S. Animal models of anxiety disorders and stress. Rev. Bras. Psiquiatr., 35(Suppl 2): S101-S111, 2013.

  9. Campos, A.C.; Ortega, Z.; Palazuelos, J.; Fogaça, M.V.; Aguiar, D.C.; Diaz-Alonso, J.; Ortega-Gutiérrez, S.; Vázquez-Villa, H.; Moreira, F.A.; Guzmán, M.; Galve-Roperh, I. & Guimarães, F.S. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Int. J. Neuropsychopharmacol., 16(6): 1407-1419, 2013.

  10. Campos, A.C.; Piorino, E.M.; Ferreira, F.R. & Guimarães, F.S. Increased nitric oxide-mediated neurotransmission in the medial prefrontal cortex is associated with the long lasting anxiogenic-like effect of predator exposure. Behav. Brain Res., 256: 391-397, 2013.

  11. Fogaça, M.V.; Galve-Roperh, I.; Guimarães, F.S. & Campos, A.C. Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link? Curr Neuropharmacol., 11(3): 263-275, 2013.

  12. Fogaça, M.V.; Gomes, F.V.; Moreira, F.A.; Guimarães, F.S. & Aguiar, D.C. Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats. Psychopharmacol., 226(3): 579-587, 2013.

  13. Gomes, F.V.; Alves, F.H.F.; Guimarães, F.S.; Corrêa, F.M.A.; Resstel, L.B.M. & Crestani, C.C. Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor. Eur. Neuropsychopharmacol., 23(9): 1096-1104, 2013.

  14. Gomes, F.V.; Del Bel, E.A. & Guimarães, F.S. Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry, 46: 43-47, 2013.

  15. Lisboa, S.F.; Magesto, A.C.; Aguiar, J.C.; Resstel, L.B.M. & Guimarães, F.S. Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats. Neuropharmacol., 75: 86-94, 2013.

  16. Nardo, M.; Casarotto, P.C.; Gomes, F.V. & Guimarães, F.S. Cannabidiol reverses the mCPP-induced increase in marble-burying behavior. Fundam. Clin. Pharmacol., 2013, in press.

  17. Pereira, V.S.; Casarotto, P.C.; Hiroaki-Sato, V.A.; Sartim, A.G.; Guimarães, F.S. & Joca, S.R.L.: Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: involvement of nitric oxide. Eur. Neuropsychopharmacol., 23(12): 1769-1778, 2013.

  18. Perez, M.; Benitez, S.U.; Cartarozzi, L.P.; Del Bel, E.A.; Guimarães, F.S. & Oliveira, A.L.R. Neuroprotection and reduction of glial reaction by cannabidiol treatment after sciatic nerve transection in neonatal rats. Eur. J. Neurosci., 38(10): 3424-3434, 2013.

  19. Scopinho, A.A.; Lisboa, S.F.S.; Guimarães, F.S.; Corrêa, F.M.A.; Resstel, L.B.M. & Joca, S.R.L. Dorsal and ventral hippocampus modulate autonomic responses but not behavioral consequences associated to acute restraint stress in rats. PLoS One, 8(10): e77750, 2013.

  20. Tonelli, D.A.G.; Pereira, M.; Siba, I.P.; Martynhak, B.J.; Correia, D.; Casarotto, P.C.; Biojone, C.; Guimarães, F.S.; Joca, S.R.L. & Andreatini, R. The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels. Fundam. Clin. Pharmacol., 27(6): 650-655, 2013.

Prof. Dr. Gustavo Ballejo Olivera

  1. Rocha JN1, Ballejo G. Nitric oxide metabolites in the lumbosacral spinal cord interstice and cerebrospinal fluid in female rats with acute cyclophosphamide-induced cystitis. An in vivo microdialysis study. Einstein (Sao Paulo) 11(1): 88-94, 2013.

Prof. Dr. Hélio Zangrossi Júnior

  1. Andrade, T.G.C.S.; Zangrossi, H., Jr. & Graeff, F.G.: The median raphe nucleus in anxiety revisited. J. Psychopharmacol., 27(12): 1107-1115, 2013.

  2. Campos, A.C.; Soares, V.P.; Carvalho, M.C.; Ferreira, F.R.; Vicente, M.A.; Brandão, M.L.; Zuardi, A.W.; Zangrossi, H., Jr. & Guimarães, F.S. Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. Psychopharmacol., 226(1): 13-24, 2013.

  3. De Bortoli, V.C.; Yamashita, P.S.M. & Zangrossi, H., Jr. 5-HT1A and 5-HT2A receptor control of a panic-like defensive response in the rat dorsomedial hypothalamic nucleus. J. Psychopharmacol., 27(12): 1116-1123, 2013.

  4. Moreira, F.A.; Gobira, P.H.; Viana, T.G.; Vicente, M.A.; Zangrossi, H. & Graeff, F. G. Modeling panic disorder in rodents. Cell. Tissue Res., 354(1): 119-125, 2013.

  5. Roncon, C.M.; Biesdorf, C.; Coimbra, N.C.; Audi, E.A.; Zangrossi, H., Jr. & Graeff, F.G.: Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and µ-receptors. J. Psychopharmacol., 27(12): 1141-1148, 2013.

  6. Strauss, C.V.A.; Vicente, M.A. & Zangrossi, H., Jr. Activation of 5-HT1A receptors in the rat basolateral amygdala induces both anxiolytic and antipanic-like effects. Behav. Brain Res., 246: 103-110, 2013.

Prof. Dr. José Carlos Farias Alves Filho

  1. Carlos, D.; Spiller, F.; Souto, F.O. Trevelin, S.C.; Borges, V.F.; de Freitas, A.; Alves-Filho, J.C.; Silva, J.S.; Ryffel, B. & Cunha, F.Q. Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model. J. Immunol., 191(3): 1373-1382, 2013.

  2. Czaikoski, P.G.; Nascimento, D.C.; Sônego, F.; de Freitas, A.; Turato, W.M.; de Carvalho, M.A.; Santos, R.S.; de Oliveira, G.P.; dos Santos Samary, C.; Tefé-Silva, C.; Alves-Filho, J.C.; Ferreira, S.H.; Rossi, M.A.; Rocco, P.R.; Spiller, F. & Cunha, F.Q. Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis. Shock, 39(4): 389-396, 2013.

  3. Garcia, C.C.; Weston-Davies, W.; Russo, R.C.; Tavares, L.P.; Rachid, M.A.; Alves-Filho, J.C.; Machado, A.V.; Ryffel, B.; Nunn, M.A. & Teixeira, M.M. Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury. PLoS ONE, 8(5): e64443, 2013.

  4. Hohmann, M. S.; Cardoso, R. D.; Pinho-Ribeiro, F. A.; Crespigio, J.; Cunha, T. M.; Alves-Filho, J. C.; Da Silva, R. V.; Pinge-Filho, P.; Ferreira, S. H.; Cunha, F. Q.; Casagrande, R. & Verri, W. A., Jr.: 5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality. Biomed. Res. Int., 2013 627046. (Electronic)

  5. Magro, D.A.C.; Hohmann, M.S.N.; Mizokami, S.S.; Cunha, T.M.; Alves-Filho, J.C.; Casagrande, R.; Ferreira, S.H.; Liew, F.Y.; Cunha, F.Q. & Verri Jr, W.A. An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice. Braz. J. Med. Biol. Res., 46(7): 601-606, 2013.

  6. Niedbala, W.; Besnard, A.G.; Jiang, H.R.; Alves-Filho, J.C.; Fukada, S.Y.; Nascimento, D.; Mitani, A.; Pushparaj, P.; Alqahtani, M.H. & Liew, F.Y. Nitric oxide-induced regulatory T cells inhibit Th17 but not Th1 cell differentiation and function. J. Immunol., 191(1): 164-170, 2013.

  7. Sesti-Costa, R.; Silva, G.K.; Proença-Módena, J.L.; Carlos, D.; Silva, M.L.; Alves-Filho, J.C.; Arruda, E.; Liew, F.Y. & Silva, J.S. The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis. J. Immunol., 191(1): 283-292, 2013.

  8. Zarpelon, A. C.; Cunha, T. M.; Alves-Filho, J. C.; Pinto, L. G.; Ferreira, S. H.; Mcinnes, I. B.; Xu, D.; Liew, F. Y.; Cunha, F. Q. & Verri, W. A., Jr. IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2. Br. J. Pharmacol., 169(1): 90-101, 2013.

Prof. Dr. José Eduardo Tanus dos Santos

  1. Amaral, J.H.; Montenegro, M.F.; Pinheiro, L.C.; Ferreira, G.C.; Barroso, R.P.; Costa-Filho, A.J. & Tanus-Santos, J. E. TEMPOL enhances the antihypertensive effects of sodium nitrite by mechanisms facilitating nitrite-derived gastric nitric oxide formation. Free Radic. Biol. Med., 65: 446-455, 2013.

  2. Amaral, L.M.; Pinheiro, L.C.; Guimarães, D.A.; Palei, A.C.; Sertório, J.T.; Portella, R.L. & Tanus-Santos, J. E. Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia. J. Cell. Mol. Med., 20 (10): 1300-1307, 2013.

  3. Andrade, V.L.; Sertório, J.T.; Eleuterio, N.M.; Tanus-Santos, J.E.; Fernandes, K.S. & Sandrim, V.C. Simvastatin treatment increases nitrite levels in obese women: Modulation by-786C polymorphism of eNOS. Nitric Oxide, 33: 83-87, 2013.

  4. Belo, V.A.; Luizon, M.R.; Carneiro, P.C.; Gomes, V.A.; Lacchini, R.; Lanna, C.M.; Souza-Costa, D.C. & Tanus-Santos, J. E. Effect of metabolic syndrome risk factors and MMP-2 genetic variations on circulating MMP-2 levels in childhood obesity. Mol. Biol. Rep., 40(3): 2697-2704, 2013.

  5. Belo, V.A.; Souza-Costa, D.C.; Lacchini, R.; Seertório, J.T.C; Lanna, C.M.; Carmo, V.P. & Tanus-Santos, J.E. Adiponectin associates positively with nitrite levels in children and adolescents. Int. J. Obes., 37(5): 740-743, 2013.

  6. Castro, M.M. & Tanus-Santos, J.E. Inhibition of matrix metalloproteinases (MMPs) as a potential strategy to ameliorate hypertension-induced cardiovascular alterations. Curr. Drug Targets, 14(3): 335-343, 2013.

  7. Cáu, S.B.A.; Barato, R.C.; Celes, M.R.; Muniz, J.J.; Rossi, M.A. & Tanus-Santos, J. E. Doxycycline prevents acute pulmonary embolism-induced mortality and right ventricular deformation in rats. Cardiovasc. Drugs Ther., 27(4): 259-267, 2013.

  8. Ceron, C.S.; Rizzi, E.; Guimarães, D.A.; Martins-Oliveira, A.; Gerlach, R.F. & Tanus-Santos, J.E. Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension. Free Radic. Biol. Med., 65: 47-56, 2013.

  9. Eleutério, N.M.; Palei, A.C.T.; Machado, J.S.R.; Tanus-Santos, J.E.; Cavalli, R.C. & Sandrim, V.C. Relationship between adiponectin and nitrite in healthy and preeclampsia pregnancies. Clin. Chim. Acta, 423: 112-115, 2013.

  10. Ferraz, K.C.; Sousa-Santos, O.; Neto-Neves, E.M.; Rizzi, E.; Muniz, J.J.; Gerlach, R.F. & Tanus-Santos, J.E. Recombinant human matrix metalloproteinase-2 impairs cardiovascular β-adrenergic responses. Basic Clin. Pharmacol. Toxicol., 112(2): 103-109, 2013.

  11. Gomes, H.F.; Palei, A.C.T.; Machado, J.S.R.; Da Silva, L.M.; Montenegro, M.F.; Jordão, A.A.; Duarte, G.; Tanus-Santos, J.E.; Cavalli, R.C. & Sandrim, V.C. Assessment of oxidative status markers and NO bioavailability in hypertensive disorders of pregnancy. J. Hum. Hypertens., 27(6): 345-348, 2013.

  12. Gonçalves, F.M.; Martins-Oliveira, A.; Lacchini, R.; Belo, V.A.; Speciali, J.G.; Dach, F. & Tanus-Santos, J.E. Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura. Gene, 512(1): 35-40, 2013.

  13. Guimarães, D.A.; Rizzi, E.; Ceron, C.S.; Pinheiro, L.C.; Gerlach, R.F. & Tanus-Santos, J.E. Atorvastatin and sildenafil lower blood pressure and improve endothelial dysfunction, but only atorvastatin increases vascular stores of nitric oxide in hypertension. Redox Biol.,1(1): 578-585, 2013.

  14. Lacchini, R.; Muniz, J.J.; Nobre, Y.T.; Cologna, A.J.; Martins, A.C. & Tanus-Santos, J.E. VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction. Pharmacogenomics J., 13(5): 437-442, 2013.

  15. Leite, L.N.; Lacchini, R.; Carnio, E.C.; Queiroz, R.H.; Tanus-Santos, J.E.; de Oliveira, A.M. & Tirapelli, C.R. Ethanol consumption increases endothelin-1 expression and reactivity in the rat cavernosal smooth muscle. Alcohol Alcohol., 48(6): 657-666, 2013.

  16. Malvezzi, H.; Aguiar, V.G.; Paz, C.C.P.; Tanus-Santos, J.E.; Penna, I.A.A. & Navarro, P.A. Increased circulating MMP-2 levels in infertile patients with moderate and severe pelvic endometriosis. Reprod. Sci., 20(5): 557-562, 2013.

  17. Martins-Oliveira, A.; Castro, M.M.; Oliveira, D.M.M.; Rizzi, E.; Ceron, C.S.; Guimarães, D.; Reis, R.I.; Costa-Neto, C.M.; Casarini, D.E.; Ribeiro, A.A.; Gerlach, R.F. & Tanus-Santos, J.E. Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling. Int. J. Cardiol., 167(4): 1199-1205, 2013.

  18. Meschiari, C.A.; Izidoro-Toledo, T.; Gerlach, R.F. & Tanus-Santos, J.E. Nitric oxide attenuates matrix metalloproteinase-9 production by endothelial cells independent of cGMP- or NFκB-mediated mechanisms. Mol. Cell. Biochem., 378(1-2): 127-135, 2013.

  19. Meschiari, C.A.; Marcaccini, A.M.; Moura, B.C.S.; Zuardi, L.R.; Tanus-Santos, J.E. & Gerlach, R.F. Salivary MMPs, TIMPs, and MPO levels in periodontal disease patients and controls. Clin. Chim. Acta, 421: 140-146, 2013.

  20. Metzger, I.F.; Luizon, M.R.; Lacchini, R.; Ishizawa, M.H. & Tanus-Santos, J.E. Effects of endothelial nitric oxide synthase tagSNPs haplotypes on nitrite levels in black subjects. Nitric Oxide, 28: 33-38, 2013.

  21. Miranda, J.A.; Belo, V.A.; Souza-Costa, D.C.; Lanna, C.M.M. & Tanus-Santos, J.E. eNOS polymorphism associated with metabolic syndrome in children and adolescents. Mol. Cell. Biochem., 372(1-2): 155-160, 2013.

  22. Miyague, A.H.; Martins, W.P.; Machado, J.S.R.; Palei, A.C.; Amaral, L.M.; Teixeira, D.M.; Sandrim, V.C.; Sertório, J.T.C.; Tanus-Santos, J.E.; Duarte, G. & Cavalli, R.C. Maternal flow-mediated dilation and nitrite concentration during third trimester of pregnancy and postpartum period. Hypertens. Pregnancy, 32(3): 225-234, 2013.

  23. Muniz, J.J.; Lacchini, R.; Rinaldi, T.O.; Nobre, Y.T.D.A.; Cologna, A.J.; Martins, A.C.P. & Tanus-Santos, J.E. Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction. Pharmacogenomics J., 13(2): 189-196, 2013.

  24. Muniz, J.J.; Lacchini, R.; Sertório, J.T.C.; Jordão, A.A., Jr.; Nobre, Y.T.D.A.; Tucci, S., Jr.; Martins, A.C.P. & Tanus-Santos, J.E. Low nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction. Naunyn-Schmiedeberg´s Arch. Pharmacol., 386(9): 805-811, 2013.

  25. Neto-Neves, E.M.; Kiss, T.; Muhl, D. & Tanus-Santos, J.E. Matrix metalloproteinases as drug targets in acute pulmonary embolism. Curr. Drug Targets, 14(3): 344-352, 2013.

  26. Neto-Neves, E.M.; Sousa-Santos, O.; Ferraz, K.C.; Rizzi, E.; Ceron, C.S.; Romano, M.M.D.; Gali, L.G.; Maciel, B.C.; Schulz, R.; Gerlach, R.F. & Tanus-Santos, J.E. Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism. J. Cell. Mol. Med., 17(12): 1588-1597, 2013.

  27. Oliveira-Paula, G.H.; Lacchini, R.; Coeli-Lacchini, F.B.; Moreno Jr., H. & Tanus-Santos, J.E. Inducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy. Gene, 515(2): 391-395, 2013.

  28. Palei, A.C.T.; Granger, J.P. & Tanus-Santos, J.E. Matrix metalloproteinases as drug targets in preeclampsia. Curr. Drug Targets, 14(3): 325-334, 2013.

  29. Quinaglia, T.; de Faria, A.P.C.; Fontana, V.; Barbaro, N.R.; Sabbatini, A.R.; Sertório, J.T.; Demacq, C.; Tanus-Santos, J.E. & Moreno, H. Acute cardiac and hemodynamic effects of sildenafil on resistant hypertension. Eur. J. Clin. Pharmacol., 69(12): 2027-2036, 2013.

  30. Rizzi, E.; Castro, M.M.; Ceron, C.S.; Neto-Neves, E.M.; Prado, C.M.; Rossi, M.A.; Tanus-Santos, J.E. & Gerlach, R.F. Tempol inhibits TGF-β and MMPs upregulation and prevents cardiac hypertensive changes. Int. J. Cardiol., 165(1): 165-173, 2013.

  31. Rizzi, E.; Ceron, C.S.; Guimarães, D.A.; Prado, C.M.; Rossi, M.A.; Gerlach, R.F. & Tanus-Santos, J.E. Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-β in renovascular hypertension-induced cardiac hypertrophy. Exp. Mol. Pathol., 94(1): 1-9, 2013.

  32. Sandrim, V.C.; Luizon, M.R.; Izidoro-Toledo, T.C.; Coelho, E.B.; Moreno, H. Jr. & Tanus-Santos, J.E. Functional VEGF haplotypes affect the susceptibility to hypertension. J. Hum. Hypertens., 27(1): 31-37, 2013.

  33. Sertório, J.T.; Lacchini, R.; Amaral, L.M.; Palei, A.C.T.; Cavalli, R.C.; Sandrim, V.C.; Duarte, G. & Tanus-Santos, J.E. Haptoglobin polymorphism affects nitric oxide bioavailability in preeclampsia. J. Human Hypertens., 27(6): 349-354, 2013.

  34. Sertório, J.T.; Neto-Neves, E.M.; Dias-Junior, C.A.; Sousa-Santos, O.; Kiss, T.; Mühl, D. & Tanus-Santos, J.E. Elevated plasma hemoglobin levels increase nitric oxide consumption in experimental and clinical acute pulmonary thromboembolism. Crit. Care Med., 41(7): e118-e124, 2013.

  35. Silva, B.R.; Pernomian, L.; Grando, M.D.; Amaral, J.H.; Tanus-Santos, J.E. & Bendhack, L.M. Hydrogen peroxide modulates phenylephrine-induced contractile response in renal hypertensive rat aorta. Eur. J. Pharmacol., 721(1-3): 193-200, 2013.

  36. Silva, P.S.; Fontana, V.; Luizon, M.R.; Lacchini, R.; Silva, W.A., Jr.; Biagi, C. & Tanus-Santos, J.E. eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril. Eur. J. Clin. Pharmacol., 69(2): 167-177, 2013.

  37. Sousa-Santos, O.; Neto-Neves, E.M.; Ferraz, K.C.; Sertório, J.T.; Portella, R.L. & Tanus-Santos, J.E. The antioxidant tempol decreases acute pulmonary thromboembolism-induced hemolysis and nitric oxide consumption. Thromb. Res., 132(5): 578-583, 2013.

  38. Tanus-Santos, J.E. Matrix metalloproteinases: a target in in-stent restenosis? Cardiol., 124(1): 49-50, 2013.

  39. Tanus-Santos, J.E. Matrix metalloproteinases: Drug targets in cardiovascular diseases (Editorial). Curr. Drug Targets, 14(3): 275, 2013.

  40. Tanus-Santos, J.E. Targeting RV failure and cardiomyocyte injury in acute pulmonary thromboembolism. Nat. Rev. Cardiol., 10(10): 559, 2013.

  41. Tanus-Santos, J.E. Antioxidant effects of phosphodiesterase-5 inhibitors. Cardiovasc. Res., 100(1): 170, 2013.

  42. Trapé, A.A.; Jacomini, A.M.; Muniz, J.J.; Seertório, J.T.C.; Tanus-Santos, J.E.; Amaral, S.L. & Zago, A.S. The relationship between training status, blood pressure and uric acid in adults and elderly. BMC Cardiovasc. Disord., 13: 44, 2013.

Prof. Dr. Leonardo Resstel Barbosa Moraes

  1. Aguiar, D.C.; Hott, S.C.; Deolindo, M.V.; Guimarães, F.S. & Resstel, L.B.M. The dorsolateral periaqueductal grey N-methyl-D-aspartate/nitric oxide/cyclic guanosine monophosphate pathway modulates the expression of contextual fear conditioning in rats. J. Psychopharmacol., 2013, in press.

  2. Alves, F.H.F.; Gomes, F.V.; Reis, D.G.; Crestani, C.C.; Corrêa, F.M.A.; Guimarães, F.S. & Resstel, L.B.M. Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning. Eur. J. Neurosci., 38(2): 2300-2307, 2013.

  3. Borelli, K.G.; Albrechet-Souza, L.; Fedoce, A.G.; Fabri, D.S.; Resstel, L.B.M. & Brandão, M.L. Conditioned fear is modulated by CRF mechanisms in the periaqueductal gray columns. Horm. Behav., 63(5): 791-799, 2013.

  4. Busnardo, C.; Alves, F.H.F.; Crestani, C.C.; Scopinho, A.A.; Resstel, L.B.M. & Corrêa, F. M. A. Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats. Eur. Neuropsychopharmacol., 23(11): 1611-1622, 2013.

  5. Busnardo, C.; Ferreira-Junior, N.C.; Cruz, J.C.; Machado, B.H.; Corrêa, F.M.A. & Resstel, L.B.M. Cardiovascular responses to ATP microinjected into the paraventricular nucleus are mediated by nitric oxide and NMDA glutamate receptors in awake rats. Exp. Physiol., 98(10): 1411-1421, 2013.

  6. Camargo, L.H.A.; Alves, F.H.F.; Biojone, C.; Corrêa, F.M.A.; Resstel, L.B.M. & Crestani, C.C. Involvement of N-methyl-D-aspartate glutamate receptor and nitric oxide in cardiovascular responses to dynamic exercise in rats. Eur. J. Pharmacol., 713(1-3): 16-24, 2013.

  7. Crestani, C.C.; Alves, F.H.F.; Gomes, F.V.; Resstel, L.B.M.; Corrêa, F.M.A. & Herman, J.P. Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: a review. Curr. Neuropharmacol., 11(2): 141-159, 2013.

  8. Da Silva, A.L.; Ruginsk, S.G.; Uchoa, E.T.; Crestani, C.C.; Scopinho, A.A.; Corrêa, F.M.A.; De Martinis, B.S.; Elias, L.L.K.; Resstel, L.B.M. & Antunes-Rodrigues, J. Time-course of neuroendocrine changes and its correlation with hypertension induced by ethanol consumption. Alcohol Alcohol., 48(4): 495-504, 2013.

  9. Deolindo, M.V.; Reis, D.G.; Crestani, C.C.; Tavares, R.F.; Resstel, L.B.M. & Corrêa, F.M.A. NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats. Eur. J. Neurosci., 38(3): 2374-2381, 2013.

  10. Ferreira-Junior, N.C.; Fedoce, A.G.; Alves, F.H.F. & Resstel, L.B.M. Medial prefrontal cortex N-methyl-D-aspartate receptor/nitric oxide/cyclic guanosine monophosphate pathway modulates both tachycardic and bradycardic baroreflex responses. J. Neurosci. Res., 91(10): 1338-1348, 2013.

  11. Gomes, F.V.; Alves, F.H.F.; Guimarães, F.S.; Corrêa, F.M.A.; Resstel, L.B.M. & Crestani, C.C. Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor. Eur. Neuropsychopharmacol., 23(9): 1096-1104, 2013.

  12. Lisboa, S.F.; Magesto, A.C.; Aguiar, J.C.; Resstel, L.B.M. & Guimarães, F.S. Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats. Neuropharmacol., 75: 86-94, 2013.

  13. Nagai, M.M.; Gomes, F.V.; Crestani, C.C.; Resstel, L.B.M. & Joca, S. R. Noradrenergic neurotransmission within the bed nucleus of the stria terminalis modulates the retention of immobility in the rat forced swimming test. Behav. Pharmacol., 24(3): 214-221,2013.

  14. Santini, C.O.; Fassini, A.; Scopinho, A.A.; Busnardo, C.; Corrêa, F.M.A. & Resstel, L.B.M. The ventral hippocampus NMDA receptor/nitric oxide/guanylate cyclase pathway modulates cardiovascular responses in rats. Auton. Neurosci.: Basic & Clin., 177(2): 244-252, 2013.

  15. Scopinho, A.A.; Lisboa, S.F.S.; Guimarães, F.S.; Corrêa, F.M.A.; Resstel, L.B.M. & Joca, S.R.L. Dorsal and ventral hippocampus modulate autonomic responses but not behavioral consequences associated to acute restraint stress in rats. PLoS One, 8(10): e77750, 2013.

  16. Terzian, A.L.; Dos Reis, D.G.; Guimarães, F.S.; Corrêa, F.M.A. & Resstel, L.B.M. Medial prefrontal cortex Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats. Psychopharmacol. (Berl)., 231(1): 149-157, 2013.

Prof. Dr. Norberto Cysne Coimbra

  1. Bertolino, G.; De Araujo, F.L.B.; Souza, H.C.D.; Coimbra, N.C. & De Araujo, J.E. Neuropathology and behavioral impairments after bilateral global ischemia surgery and exposure to static magnetic field: Evidence in the motor cortex, the hippocampal CA1 region and the neostriatum. Int. J. Radiat. Biol., 89(8): 595-601, 2013.

  2. Biagioni, A.F.; De Freitas, R.L.; Da Silva, J.A.; De Oliveira, R.C.; De Oliveira, R.; Alves, V.M. & Coimbra, N.C. Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways. Neuropharmacol., 67: 379-394, 2013.

  3. Da Silva, J.A.; De Freitas, R.L.; Eichenberger, G.C.D.; Padovan, C.M. & Coimbra, N.C. Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour. Eur. J. Pharmacol., 698(1-3): 235-245, 2013.

  4. Da Silva, L.FS..; Coimbra, N.C. & Menescal-de-Oliveira, L. Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: A biotinylated dextran amine neurotracing study. Neurosci. Lett., 535: 116-121, 2013.

  5. De Freitas, R.L.; Bolognesi, L.I.; Twardowschy, A.; Corrêa, F.M.A.; Sibson, N. R. & Coimbra, N.C. Neuroanatomical and neuropharmacological approaches to postictal antinociception-related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors. Brain Behav., 3(3): 286-301, 2013.

  6. De Freitas, R.L.; Salgado-Rohner, C.J.; Hallak, J.E.C.; Crippa, J.A.S. & Coimbra, N.C. Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor. Int. J. Neuropsychopharmacol., 16(8): 1781-1798, 2013.

  7. Twardowschy, A.; Castiblanco-Urbina, M.A.; Uribe-Marino, A.; Biagioni, A.F.; Salgado-Rohner, C.J.; Crippa, J.A.S. & Coimbra, N.C. The role of 5-HT1A receptors in the anti-aversive effects of cannabidiol on panic attack-like behaviors evoked in the presence of the wild snake Epicrates cenchria crassus (Reptilia, Boidae). J. Psychopharmacol., 27(12): 1149-1159, 2013.

  8. Roncon, C.M.; Biesdorf, C.; Coimbra, N.C.; Audi, E.A.; Zangrossi, H., Jr. & Graeff, F.G.: Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and µ-receptors. J. Psychopharmacol., 27(12): 1141-1148, 2013.

Profa. Dra. Rita de Cássia Aleixo Tostes Passaglia

  1. Carvalho-de-Souza, J.L.; Varanda, W.A.; Tostes, R.C. & Chignalia, A.Z. BK channels in cardiovascular diseases and aging. Aging Dis., 4(1): 38-49, 2013.

  2. Carrillo-Sepulveda, M.A.; Ceravolo, G.S.; Furstenau, C.R.; Monteiro, P.S.; Bruno-Fortes, Z.; Carvalho, M.H.; Laurindo, F.R.; Tostes, R.C.; Webb, R.C. & Barreto-Chaves, M.L.M. Emerging role of angiotensin type 2 receptor (AT2R)/Akt/NO pathway in vascular smooth muscle cell in the hyperthyroidism. PLoS ONE, 8(4): e61982, 9 pages, 2013.

  3. Ceravolo, G.S.; Filgueira, F.P.; Costa, T.J.; Lobato, N.S.; Chignalia, A.Z.; Araujo, P.X.; Tostes, R.C.; Dantar, A.P.; Fortes, Z.B. & Carvalho, M.H.C. Conjugated equine estrogen treatment corrected the exacerbated aorta oxidative stress in ovariectomized spontaneously hypertensive rats. Steroids, 78(3): 341-346, 2013.

  4. Chiao, C-W.; da Silva-Santos, J.E.; Giachini, F.R.; Tostes, R.C.; Su, M.J. & Webb, R.C. P2X7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction. Clin. Sci. (Lond), 125(3): 131-141, 2013.

  5. Labazi, H.; Wynne, B.M.; Tostes, R. & Webb, R.C.: Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. J. Sex. Med., 10(9): 2154-2164, 2013.

  6. Li, W.; Prakash, R.; Chawla, D.; Du, W.; Didion, S.P.; Filosa, J.A.; Zhang, Q.; Brann, D.W.; Lima, V.V.; Tostes, R.C. & Ergul, A. Early effects of high-fat diet on neurovascular function and focal ischemic brain injury. Am. J. Physiol. Regul. Integr. Comp. Physiol., 304(11): R1001-R1008, 2013.

  7. Lobato, N.S.; Filgueira, F.P.; Prakash, R.; Giachini, F.R.; Ergul, A.; Carvalho, M.H.C.; Webb, R.C.; Tostes, R.C. & Fortes, Z.B. Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. PLoS ONE, 8(5): e63449, 11 pages, 2013.

  8. Tezini, G.C.S.V.; Becari, C.; Zanotto, C.Z.; Salgado, M.C.O.; Passaglia, R.C.A.T. & Souza, H.C.D. Ageing is the main determinant of haemodynamics and autonomic cardiac changes observed in post-menopausal female rats. Auton. Neurosc.: Basic & Clinical, 174: 36-41, 2013.

Prof. Dr. Thiago Mattar Cunha

  1. Carreira, E.U.; Carregaro, V.; Teixeira, M.M.; Moriconi, A.; Aramini, A.; Verri Jr., W.A.; Ferreira, S.H.; Cunha, F.Q. & Cunha, T.M. Neutrophils recruited by CXCR1/2 signalling mediate post-incisional pain. Eur. J. Pain, 17(5): 654-663, 2013.

  2. De Luca, B.; Xavier-Elsas, P.; Barradas, M.; Luz, R. A.; Queto, T.; Jones, C.; Arruda, M. A.; Cunha, T. M.; Cunha, F. Q. & Gaspar-Elsas, M. I. Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents. Scientific World Journal., 2013, 208705 (Electronic).

  3. Donate, P.B.; Fornari, T.A.; Macedo, C.; Cunha, T.M.; Nascimento, D.C.B.; Sakamoto-Hojo, E.T.; Donadi, E.A.; Cunha, F.Q. & Passos, G.A. T cell post-transcriptional Mirna-mRNA interaction networks identify targets associated with susceptibility/resistance to collagen-induced arthritis. PloS ONE, 8(1): e54803, 2013.

  4. Figueiredo, J.; Ferreira, A.E.; Silva, R.L.; Ulloa, L.; Grieco, P.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q. & Kanashiro, A. NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. Naunyn-Schmiedeberg’s Arch. Pharmacol., 386(4): 311-318, 2013.

  5. Franchin, M.; Cunha, M.G.; Denny, C.; Napimoga, M.H.; Cunha, T.M.; Bueno-Silva, B.; Alencar, S.M.; Ikegaki, M. & Rosalen, P.L. Bioactive fraction of geopropolis from Melipona scutellaris decreases neutrophils migration in the inflammatory process: Involvement of nitric oxide pathway. Evid. Based Complement Alternat. Med., 2013: Article ID 907041, 9 pages, 2013.

  6. Guerrero, A.T.; Zaperlon, A.C.; Vieira, S.M.; Pinto, L.G.; Ferreira, S.H.; Cunha, F.Q.; Verri Jr., W.A.; & Cunha, T.M. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. Naunyn-Schmiedeberg´s Arch. Pharmacol., 386(1): 51-59, 2013.

  7. Hohmann, M. S.; Cardoso, R. D.; Pinho-Ribeiro, F. A.; Crespigio, J.; Cunha, T. M.; Alves-Filho, J. C.; Da Silva, R. V.; Pinge-Filho, P.; Ferreira, S. H.; Cunha, F. Q.; Casagrande, R. & Verri, W. A., Jr.: 5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality. Biomed. Res. Int., 2013 627046. (Electronic).

  8. Magro, D.A.C.; Hohmann, M.S.N.; Mizokami, S.S.; Cunha, T.M.; Alves-Filho, J.C.; Casagrande, R.; Ferreira, S.H.; Liew, F.Y.; Cunha, F.Q. & Verri Jr, W.A. An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice. Braz. J. Med. Biol. Res., 46(7): 601-606, 2013.

  9. Santos, D.S.; Marta, I.E.R.; Cárnio, E.C.; Quadros, A.U.; Cunha, T.M. & Carvalho, E.C. Using na experimental model for the study of therapeutic touch. Rev. Latino-Am. Enfermagem, 21(1): 442-449, 2013.

  10. Souza, G.R.; Talbot, J.; Lotufo, C.M.; Cunha, F.Q.; Cunha, T.M. & Ferreira, S.H. Fractalkine mediates inflammatory pain through activation of satellite glial cells. Proc. Natl. Acad. Sci. USA., 110(27): 11193-11198, 2013.

  11. Vercelino, R.; Cunha, T.M.; Ferreira, E.S.; Cunha, F.Q.; Ferreira, S.H. & Oliveira, M.G. Skin vasodilation and analgesic effect of a topical nitric oxide-releasing hydrogel. J. Mater Sci: Mater Med., 24(9): 2157-2169, 2013.

  12. Zarpelon, A. C.; Cunha, T. M.; Alves-Filho, J. C.; Pinto, L. G.; Ferreira, S. H.; Mcinnes, I. B.; Xu, D.; Liew, F. Y.; Cunha, F. Q. & Verri, W. A., Jr. IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2. Br. J. Pharmacol., 169(1): 90-101, 2013.

  13. Zarpelon, A.C.; Souza, G.R.; Cunha, T.M.; Schivo, I.R.S.; Marchesi, M.; Casagrande, R.; Pinge-Filho, P.; Cunha, F.Q.; Ferreira, S.H.; Miranda, K.M. & Verri Jr., W.A. The nitroxyl donor, Angeli´s salt, inhibits inflammatory hyperalgesia in rats. Neuropharmacol., 71: 1-9, 2013.

Prof. Dr. Sérgio Henrique Ferreira

  1. Abrantes, V.E.F.; Matias da Rocha, B.A.; Batista da Nóbrega, R.; Silva-Filho, J. C.; Teixeira, C.S.; Cavada, B.S.; Gadelha, C.A.A.; Ferreira, S. H.; Figueiredo, J.G.; Santi-Gadelha, T. & Delatorre, P. Molecular modeling of lectin-like protein from Acácia farnesiana reveals a possible anti-inflammatory mechanism in carrageenan-induced inflammation. Biomed. Res. Int., 2013: Article ID 253483, 9 pages.

  2. Araldi, D.; Ferrari, L.F.; Lotufo, C.M.; Vieira, A.S.; Athié, M.C.P.; Figueiredo, J.G.; Duarte, D.B.; Tambeli, C.H.; Ferreira, S. H. & Parada, C.A. Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion. Proc. Natl. Acad. Sci. USA, 110(9): 3603-3608, 2013.

  3. Carreira, E.U.; Carregaro, V.; Teixeira, M.M.; Moriconi, A.; Aramini, A.; Verri Jr., W.A.; Ferreira, S.H.; Cunha, F.Q. & Cunha, T.M. Neutrophils recruited by CXCR1/2 signalling mediate post-incisional pain. Eur. J. Pain, 17(5): 654-663, 2013.

  4. Czaikoski, P.G.; Nascimento, D.C.; Sônego, F.; de Freitas, A.; Turato, W.M.; de Carvalho, M.A.; Santos, R.S.; de Oliveira, G.P.; dos Santos Samary, C.; Tefé-Silva, C.; Alves-Filho, J.C.; Ferreira, S.H.; Rossi, M.A.; Rocco, P.R.; Spiller, F. & Cunha, F.Q. Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis. Shock, 39(4): 389-396, 2013.

  5. Figueiredo, J.; Ferreira, A.E.; Silva, R.L.; Ulloa, L.; Grieco, P.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q. & Kanashiro, A. NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. Naunyn-Schmiedeberg´s Arch. Pharmacol., 386(4): 311-318, 2013.

  6. Guerrero, A.T.; Zaperlon, A.C.; Vieira, S.M.; Pinto, L.G.; Ferreira, S.H.; Cunha, F.Q.; Verri Jr., W.A.; & Cunha, T.M. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. Naunyn-Schmiedeberg´s Arch. Pharmacol., 386(1): 51-59, 2013.

  7. Magro, D.A.C.; Hohmann, M.S.N.; Mizokami, S.S.; Cunha, T.M.; Alves-Filho, J.C.; Casagrande, R.; Ferreira, S.H.; Liew, F.Y.; Cunha, F.Q. & Verri Jr, W.A. An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice. Braz. J. Med. Biol. Res., 46(7): 601-606, 2013.

  8. Souza, G.R.; Talbot, J.; Lotufo, C.M.; Cunha, F.Q.; Cunha, T.M. & Ferreira, S.H. Fractalkine mediates inflammatory pain through activation of satellite glial cells. Proc. Natl. Acad. Sci. USA, 110(27): 11193-11198, 2013.

  9. Vercelino, R.; Cunha, T.M.; Ferreira, E.S.; Cunha, F.Q.; Ferreira, S.H. & Oliveira, M.G. Skin vasodilation and analgesic effect of a topical nitric oxide-releasing hydrogel. J. Mater Sci: Mater Med., 24(9): 2157-2169, 2013.

  10. Villarreal, C.F.; Funez, M.I.; Cunha, F.Q.; Parada, C.A. & Ferreira, S.H. The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice. Pharmacol. Biochem. Behav., 103(3): 678-683, 2013.

  11. Zarpelon, A.C.; Souza, G.R.; Cunha, T.M.; Schivo, I.R.S.; Marchesi, M.; Casagrande, R.; Pinge-Filho, P.; Cunha, F.Q.; Ferreira, S.H.; Miranda, K.M. & Verri Jr., W.A. The nitroxyl donor, Angeli´s salt, inhibits inflammatory hyperalgesia in rats. Neuropharmacol., 71: 1-9, 2013.

Prof. Dr. Wiliam Alves do Prado

  1. Dias, Q.M.; Rossaneis, A.C.; Fais, R.S. & Prado, W.A. An improved experimental model for peripheral neuropathy in rats. Braz. J. Med. Biol. Res., 46(3): 253-256, 2013.

  2. Fais, R.S.; Reis, G.M.; Dias, Q.M.; Rossaneis, A.C.; Silveira, J.W.S. & Prado, W.A. Amitriptyline prolongs the antihyperalgesic effect of 2Hz electroacupuncture in mononeuropathic rats. Acupuncture and Related Therapies, 1: 20-26, 2013.

  3. Genaro, K.; Juliano, M.A.; Prado, W.A.; Brandão, M.L. & Martins, A.R. Effects of angiotensin (5-8) microinfusions into the ventrolateral periaqueductal gray on defensive behaviors in rats. Behav. Brain Res., 256: 537-544, 2013.

  4. Guethe, L.M.; Pelegrini-da-Silva, A.; Borelli, K.G.; Juliano, M.A.; Pelosi, G.G.; Pesquero, J.B.; Silva, C.L.M.; Corrêa, F.M.A.; Murad, F.; Prado, W.A. & Martins, A.R. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience 231: 315-327, 2013.

  5. Silva, J.R.T.; Silva, M.L. & Prado, W.A. Spinal mediatioon of descending pain inhibitorsy mechanisms activated by 2/100-Hz electroacupunture in the rata tail-flick test. Acupunture and Related Therapies, 1: 15-19, 2013.

  6. Silva, J.R.T.; Silva, M.L. & Prado, W.A. Electroacupuncture at 2/100 Hz activates antinociceptive spinal mechanisms different from those activated by electroacupuncture at 2 and 100 Hz in responder rats. Evid Based Complement Alternat Med. 2013; 2013: 205316. Published online 2013 September 16. doi: 10.1155/2013/205316 (Não existe no. de página por ser on line).

  7. Silva, M.L.; Silva, J.R.T. & Prado, W.A. Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the anterior pretectal nucleus. Life Sci., 93(20): 742-754, 2013.

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