Publicações

Nesta página: publicações do ano de 2014

Prof. Dr. Fernando de Queiróz Cunha

  1. Barbosa, A.L.R.; Sousa, R.B.;Torres, J.N.L.; Cunha, T.M.; Cunha, F.Q.; Soares, P.M.G.; Ribeiro. R.A.; Vale, M.L. & Souza, M.H.L.P. Colitis generates remote antinociception in rats: the role of the L-arginine/NO/cGMP/PKG/KATP pathway and involvement of cannabinoid and opioid systems. Inflamm. Res., 63(12): 969-977, 2014.

  2. Barragán-Iglesias, P.; Rocha-González, H.I.; Pineda-Farias, J. B.; Murbartián, J.; Godínez-Chaparro, B.; Reinach, P.S.; Cunha, T.M.; Cunha, F.Q. & Granados-Soto, V. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. Eur. J. Pharmacol., 738: 91-100, 2014.

  3. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66(7): 1009-1020, 2014.

  4. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R.D.R.; Martins-Pinge, M.C.; Tatakihara, R.I.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr.: Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice. Physiol. & Behav., 128: 277-287, 2014.

  5. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  6. Canavaci, A.M.C.; Sorgi, C.A.; Martins, V.P.; Morais, F.R.; De Sousa, E.V.G.; Trindade, B.C.; Cunha, F.Q.; Rossi, M.A.; Aronoff, D.M.; Faccioli, L.H. & Nomizo, A. The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice. Med. Inflamm., Vol. 2014, Article ID 893634, 2014.

  7. Carmona, F.; Manso, P.H.; Silveira, V.S.; Cunha, F.Q.; De Castro, M. & Carlotti, A.P.C.P.: Inflammation, myocardial dysfunction, and mortality in children with septic shock: an observational study. Pediatr. Cardiol., 35(3): 463-470, 2014.

  8. De Aquino, S.G.; Abdollahi-Roodsaz, S.; Koenders, M.I.; Van De Loo, F.A.J.; Pruijn, G.J.M.; Marijnissen, R.J.; Walgreen, B.; Helsen, M.M.; Van Den Bersselaar, L.A.; De Molon, R.S.; Avila Campos, M.J.; Cunha, F.Q.; Cirelli, J.A. & Van Den Berg, W. B. Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response. J. Immunol., 192(9): 4103-4111, 2014.

  9. Ferreira, A.E.; Sisti, F.; Sônego, F.; Wang, S.; Filgueiras, L.R.; Brandt, S.; Serezani, A.P.M.; Du, H.; Cunha, F.Q.; Alves-Filho, J.C. & Serezani, C.H. PPAR-y/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J. Immunol., 192(5): 2357-2365, 2014.

  10. Guabiraba, R.; Besnard, A.G.; Menezes, G.B.; Secher, T.; Jabir, M.S.; Amaral, S.S.; Braun, H.; Lima-Junior, R.C.P.; Ribeiro, R.A.; Cunha, F.Q.; Teixeira, M.M.; Beyaert, R.; Graham, G.J. & Liew, F.Y. IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice. Mucosal Immunol., 7(5): 1079-1093, 2014.

  11. Gutierrez, F.R.S.; Pavanelli, W.R.; Medina, T.S.; Silva, G.K.; Mariano, F.S.; Guedes, P.M.M.; Mineo, T.W.P.; Rossi, M.A.; Cunha, F.Q. & Silva, J.S. Haeme oxygenase activity protects the host against excessive cardiac inflammation during experimental Trypanosoma cruzi infection. Microbes Infect., 16(1): 28-39, 2014.

  12. Hernandes, M.S.; D'Avila, J.C.; Trevelin, S.C.; Reis, P.A.; Kinjo, E.R.; Lopes, L.R.; Castro-Faria-Neto, H.C.; Cunha, F. Q.; Britto, L.R.G. & Bozza, F.A. The role of Nox2-derived ROS in the development of cognitive impairment after sepsis. J. Neuroinflamm., 11: 36-48, 2014.

  13. Leite, A.C.R.M.;Teotonio, M.A.A.; Girão, V.C.C.; Pompeu, M.M.L.; Nunes, R.M.; Cunha, T.M.; Pinto, A.C.M.D.; Cunha, F.Q. & Rocha, F.A.C. Meniscal transaction rather than excision increases pain behavior and structural damage in experimental osteoarthritis in mice. Osteoarth. Cartilage, 22(11):1878-1885, 2014.

  14. Lima-Junior, R.C.P.; Freitas, H.C.; Wong, D.V.T.; Wanderley, C.W.S.; Nunes, L.G.; Leite, L.L.; Miranda, S.P.; Souza, M.H.L.P.; Brito, G.A.C.; Magalhães, P.J.C.; Teixeira, M.M.; Cunha, F.Q. & Ribeiro, R.A. Targeted inhibition of IL-18 attenuates irinotecan-induced intestinal mucositis in mice. Br. J. Pharmacol., 171(9): 2335-2350, 2014.

  15. Mendonça, M.A.O.; Souto, F.O.; Micheli, D.C.; Alves-Filho, J. C.; Cunha, F.Q.; Murta, E.F.C. & Tavares-Murta, B.M. Mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy. Cancer Chemother. Pharmacol., 73(2): 317-324, 2014.

  16. Moriconi, A.; Cunha, T.M.; Souza, G.R.; Lopes, A.H.; Cunha, F.Q.; Carneiro, V. L.; Pinto, L.G.; Brandolini, L.; Aramini, A.; Bizzarri, C.; Bianchini, G.; Beccari, A.R.; Fanton, M.; Bruno, A.; Costantino, G.; Bertini, R.; Galliera, E.; Locati, M.; Ferreira, S.H.; Teixeira, M.M. & Allegretti, M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc. Natl. Acad. Sci. U S A., 111(47): 16937-16942, 2014.

  17. Prates, T.P.; Taira, T.M.; Holanda, M.C.; Bignardi, L.A.; Salvador, S.L.; Zamboni, D.S.; Cunha, F.Q. & Fukada, S.Y. NOD2 contributes to Porphyromonas gingivalis-induced bone resorption. J. Dent. Res., 93(11): 1155-1162, 2014.

  18. Sacramento, L.A.; Cunha, F.Q.; De Almeida, R.P.; Silva, J.S. & Carregaro, V. Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset. Biomed. Res. Int., Vol. 2014, Article ID 264270, 2014.

  19. Saia, R.S.; Mestriner, F.L.; Bertozi, G.; Cunha, F.Q. & Carnio, E.C. Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages. Med. Inflamm., Vol. 2014: Article ID 896029, 2014.

  20. Sônego, F.; Alves-Filho, J.C. & Cunha, F.Q.: Targeting neutrophils in sepsis. Expert Rev. Clin. Immunol., 10(8): 1019-1028, 2014.

  21. Sônego, F.; Castanheira, F.V.S; Czaikoski, P.G.; Kanashiro, A.; Souto, F.O.; França, R.O.; Nascimento, D.C.; Freitas, A.; Spiller, F.; Cunha, L.D.; Zamboni, D.S.; Alves-Filho, J.C.F. & Cunha, F.Q. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS One, 9(8): e103734, 2014.

  22. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.

  23. Vieira, S.M.; Silva, R.L.; Lemos, H.P.; Amorim, R.C.N.; Silva, E.C.C.; Reinach, P.S.; Cunha, F.Q.; Pohlit, A.M. & Cunha, T. M. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, 95: 8-15, 2014.

  24. Wanderley, C.W.S.; Silva, C.M.S.; Wong, D.V.T.; Ximenes, R. M.; Morelo, D.F.C.; Cosker, F.; Aragão, K.S.; Fernandes, C.; Palheta-Junior, R.C.; Havt, A.; Brito, G.A.C.; Cunha, F.Q.; Ribeiro, R.A. & Lima-Junior, R.C.P. Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner. Toxicon, 90 134-147, 2014.

Prof. Dr. Fernando Morgan de Aguiar Corrêa

  1. Alves, F.H.F.; Crestani, C.C.; Resstel, L.B.M. & Corrêa, F.M.A. Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. PLoS One, 9(1): e83900, 2014.

  2. Busnardo, C.; Tavares, R.F. & Corrêa, F.M.A. Angiotensinergic neurotransmission in the paraventricular nucleus of the hypothalamus modulates the pressor response to acute restraint stress in rats. Neurosc., 270: 12-19, 2014.

  3. De Freitas, R.L.; De Oliveira, R.C.; De Oliveira, R.; Paschoalin-Maurin, T.; Corrêa, F.M.A. & Coimbra, N.C. The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT(2)A and 5-HT(2)C serotonergic receptors in post-ictal antinociception. Synapse, 68(1): 16-30, 2014.

  4. Fassini, A.; Scopinho, A.A.; Resstel, L.B.M. & Corrêa, F.M.A. Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat. Neuropharmacol., 85: 367-374, 2014.

  5. Moraes-Neto, T.B.; Scopinho, A.A.; Biojone, C.; Corrêa, F.M.A. & Resstel, L.B.M. Involvement of dorsal hippocampus glutamatergic and nitrergic neurotransmission in autonomic responses evoked by acute restraint stress in rats. Neuroscience, 258: 364-373, 2014.

  6. Reis, D.G.; Fortaleza, E.A.T.; Tavares, R.F. & Corrêa, F.M.A. Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats. Stress, 17(4): 362-372, 2014.

  7. Terzian, A.L.B.; Reis, D.G.; Guimarães, F.S.; Corrêa, F.M.A. & Resstel, L.B.M. Medial prefrontal cortex Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats. Psychopharmacol. (Berl), 231(1): 149-157, 2014.

  8. Crestani, C.C.; Silva, A.L.; Scopinho, A.A.; Ruginsk, S.G.; Uchoa, E.T.; Corrêa, F.M.A.; Elias, L.L.K.; Antunes-Rodrigues, J. & Resstel, L.B.M. Cardiovascular alterations at different stages of hypertension development during ethanol consumption: Time-course of vascular and autonomic changes. Toxicol. Appl. Pharmacol., 280(2): 245-255, 2014.

  9. Fabri, D.R.S.; Hott, S.C.; Reis, D.G.; Biojone, C.; Corrêa, F.M.A. & Resstel, L.B.M. The expression of contextual fear conditioning involves activation of a NMDA receptor-nitric oxide-cGMP pathway in the dorsal hippocampus of rats. Eur. Neuropsychopharmacol., 24(10): 1676-1686, 2014.

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Prof. Dr. Francisco Silveira Guimarães

  1. Aguiar, D.C.; Hott, S.C.; Deolindo, M.V.; Guimarães, F.S. & Resstel, L.B.M. The dorsolateral periaqueductal grey N-methyl-D-aspartate/nitric oxide/cyclic guanosine monophosphate pathway modulates the expression of contextual fear conditioning in rats. J. Psychopharmacol., 28(5): 479-485,2014.

  2. Aguiar, D.C.; Moreira, F.A.; Terzian, A.L.; Fogaça, M.V.; Lisboa, S.F.; Wotjak, C.T. & Guimarães, F.S. Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels. Neurosci. Biobehav. Rev., 46(3): 418-428, 2014.

  3. Batalla, A.; Crippa, J.A.; Busatto, G.F.; Guimarães, F.S.; Zuardi, A.W.; Valverde, O.; Atakan, Z.; McGuire, P.K.; Bhattacharyya, S. & Martin-Santos, R. Neuroimaging of acute of THC and CBD in humans and animals: a systematic review. Curr. Pharm. Des., 20(13): 2168-2185, 2014.

  4. Del-Bel, E.; Padovan-Neto, F.E.; Szawka, R.E.; Da-Silva, C. A.; Raisman-Vozari, R.; Anselmo-Franci, J.; Romano-Dutra, A. C. & Guimarães, F.S. Counteraction by nitric oxide synthase inhibitor of neurochemical alterations of dopaminergic system in 6-OHDA-lesioned rats under ʟ-DOPA treatment. Neurotox Res., 25(1): 33-44, 2014.

  5. Fogaça, M.V.; Reis, F.M.C.V.; Campos, A.C. & Guimarães, F. S. Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience. Eur. Neuropsychopharmacol., 24(3): 410-419, 2014.

  6. Gomes, F.V.; Kakihata, A.M.; Semedo, A.C.G.; Hott, S.C.; Uliana, D.L.; Guimarães, F.S. & Resstel, L.B.M. D-cycloserine injected into the dorsolateral periaqueductal gray induces anxiolytic-like effects in rats. Behav. Brain Res., 271: 374-379, 2014.

  7. Lisboa, S.F.; Camargo, L.H.A.; Magesto, A.C.; Resstel, L.B.M. & Guimarães, F.S. Cannabinoid modulation of predator fear: involvement of the dorsolateral periaqueductal gray. Int. J. Neuropsychopharmacol., 17(8): 1193-1206, 2014.

  8. Nardo, M.; Casarotto, P.C.; Gomes, F.V. & Guimarães, F.S. Cannabidiol reverses the mCPP-induced increase in marble-burying behavior. Fundam. Clin. Pharmacol., 28(5): 544-550, 2014.

  9. Schiavon, A.P.; Soares, L.M.; Bonato, J.M.; Milani, H.; Guimarães, F.S. & Oliveira, R.M.W. Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice. Neurotox. Res., 26(4): 307-316, 2014.

  10. Silveira, J.W.; Issy, A.C.; Castania, V.A.; Salmon, C.E.G.; Nogueira-Barbosa, M.H.; Guimarães, F.S.; Defino, H.L.A. & Del Bel, E. Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. PLoS One, 9(12): e113161, 2014.

  11. Terzian, A.L.B.; Reis, D.G.; Guimarães, F.S.; Corrêa, F.M.A. & Resstel, L.B.M. Medial prefrontal cortex Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the expression of contextual fear conditioning in Wistar rats. Psychopharmacol. (Berl), 231(1): 149-157, 2014.

Prof. Dr. José Carlos Farias Alves Filho

  1. Barbour, M.; Allan, D.; Xu, H.; Pei, C.; Chen, M.; Niedbala, W.; Fukada, S.Y.; Besnard, A-G.; Alves-Filho, J.C.; Tong, X.; Forrester, J.V.; Liew, F.Y. & Jiang, H-R. IL-33 attenuates the development of experimental autoimmune uveitis. Eur. J. Pharmacol., 44(11): 3320-3329, 2014.

  2. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66(7): 1009-1020, 2014.

  3. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  4. Ferreira, A.E.; Sisti, F.; Sônego, F.; Wang, S.; Filgueiras, L.R.; Brandt, S.; Serezani, A.P.M.; Du, H.; Cunha, F.Q.; Alves-Filho, J.C. & Serezani, C.H. PPAR-y/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J. Immunol., 192(5): 2357-2365, 2014.

  5. Mendonça, M.A.O.; Souto, F.O.; Micheli, D.C.; Alves-Filho, J. C.; Cunha, F.Q.; Murta, E.F.C. & Tavares-Murta, B.M. Mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy. Cancer Chemother. Pharmacol., 73(2): 317-324, 2014.

  6. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.

  7. Sônego, F.; Alves-Filho, J.C. & Cunha, F.Q.: Targeting neutrophils in sepsis. Expert Rev. Clin. Immunol., 10(8): 1019-1028, 2014.

  8. Sônego, F.; Castanheira, F.V.S; Czaikoski, P.G.; Kanashiro, A.; Souto, F.O.; França, R.O.; Nascimento, D.C.; Freitas, A.; Spiller, F.; Cunha, L.D.; Zamboni, D.S.; Alves-Filho, J.C.F. & Cunha, F.Q. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS One, 9(8): e103734, 2014.

Prof. Dr. José Eduardo Tanus dos Santos

  1. Antonio, R.C.; Ceron, C.S.; Rizzi, E.; Coelho, E. B.; Tanus-Santos, J.E. & Gerlach, R.F. Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR. Mol. Cell. Biochem., 386(1-2): 99-105, 2014.

  2. Castro, M.M. & Tanus-Santos, J.E. Targeting matrix metalloproteinases in disease conditions. Acupunct. Med., 32(5): 373-375, 2014.

  3. Eleutério, N.M.; Palei, A.C.T.; Machado, J.S.R.; Tanus-Santos, J.E.; Cavalli, R.C. & Sandrim, V.C. Correlations between circulating levels of adipokines and anti-angiogenic factors in women with BMI <30 and a late-onset preeclampsia. Hypertens. Pregnancy, 33(1): 72-80, 2014.

  4. Fontana, V.; De Faria, A.P.C.; Oliveira-Paula, G.H.; Silva, P. S.; Biagi, C.; Tanus-Santos, J.E. & Moreno, H. Effects of angiotensin-converting enzyme inhibition on leptin and adiponectin levels in essential hypertension. Basic & Clin. Pharmacol. Toxicol., 114(6): 472-475, 2014.

  5. Lacchini, R.; Luizon, M.R.; Gasparini, S.; Ferreira-Sae, M.C.; Schreiber, R.; Nadruz, W., Jr. & Tanus-Santos, J.E. Effect of genetic polymorphisms of vascular endothelial growth factor on left ventricular hypertrophy in patients with systemic hypertension. Am. J. Cardiol., 113(3): 491-496, 2014.

  6. Lacchini, R.; Muniz, J.J.; Nobre, Y.T.D.A.; Cologna, A.J.; Martins, A.C.P. & Tanus-Santos, J.E. nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction. Pharmacogenomics, 15(6): 775-784, 2014.

  7. Lacchini, R. & Tanus-Santos, J.E. Pharmacogenetics of erectile dysfunction: navigating into uncharted waters. Pharmacogenomics, 15(11): 1519-1538, 2014.

  8. Luizon, M.R.; Palei, A.C.T.; Sandrim, V.C.; Amaral, L.M.; Machado, J.S.R.; Lacchini, R.; Cavalli, R.C.; Duarte, G. & Tanus-Santos, J.E. Tissue inhibitor of matrix metalloproteinase-1 polymorphism, plasma TIMP-1 levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy. The Pharmacogenomics J., 14(6): 535-541, 2014.

  9. Machado, J.S.R.; Palei, A.C.T.; Amaral, L.M.; Bueno, A.C.; Antonini, S.R.; Duarte, G.; Tanus-Santos, J.E.; Sandrim, V. C. & Cavalli, R.C. Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia. J. Human Hypertens., 28(2): 128-132, 2014.

  10. Montenegro, M.F.; Pinheiro, L.C.; Amaral, J.H.; Ferreira, G. C.; Portella, R.L. & Tanus-Santos, J.E. Vascular xanthine oxidoreductase contributes to the antihypertensive effects of sodium nitrite in ʟ-NAME hypertension. Naunyn- Schmiedeberg´s Arch. Pharmacol., 387(6): 591-598, 2014.

  11. Oliveira-Paula, G.H.; Lacchini, R. & Tanus-Santos, J.E. Inducible nitric oxide synthase as a possible target in hypertension. Curr. Drug Targets, 15(2): 164-174, 2014.

  12. Pinheiro, L.C.; Amaral, J.H.; Ferreira, G.C.; Montenegro, M.F.; Oliveira-Paula, G.H. & Tanus-Santos, J.E. The antihypertensive effects of sodium nitrite are not associated with circulating angiotensin converting enzyme inhibition. Nitric Oxide, 40: 52-59, 2014.

  13. Rezende, V.B.; Barbosa, F., Jr.; Palei, A.C.; Cavalli, R.C.; Tanus-Santos, J.E. & Sandrim, V.C. Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy. J. Trace Elem. Med. Biol., 29: 130-135, 2014.

  14. Rizzi, E.; Guimarães, D.A.; Ceron, C.S.; Prado, C.M.; Pinheiro, L.C.; Martins-Oliveira, A.; Gerlach, R.F. & Tanus-Santos, J. E. β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free Radic. Biol. Med., 73: 308-317, 2014.

  15. Silva, R.F.; Sertório, J.T.C.; Lacchini, R.; Trapé, A.A.; Tanus-Santos, J.E.; Rush, J.W.E.; Amaral, S.L. & Zago, A.S. Influence of training status and eNOS haplotypes on plasma nitrite concentrations in normotensive older adults: a hypothesis-generating study. Aging Clin. Exp. Res., 26(6): 591-598, 2014.

  16. Villela, M.P.; Andrade, V.L.; Eccard, B.; Jordão, A.A.; Sertório, J.T.; Tanus-Santos, J.E.; Silva, I.F.; Silveira, J.N. & Sandrim, V.C. Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin. Clin. Exp. Pharmacol. Physiol., 41(10): 744-747, 2014.

  17. Windsant, I.C.V.; De Wit, N.C.J.; Sertorio, J.T.C.; Van Bijnen, A.A.; Ganushchak, Y.M.; Heijmans, J.H.; Tanus-Santos, J.E.; Jacobs, M.J.; Maessen, J.G. & Buurman, W.A. Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Frontiers Physiol., 5: Article 340(1-9), 2014.

  18. Zago, V.H.S.; Tanus-Santos, J.E.; Danelon, M.R.G.; Parra, E.S.; Alexandre, F.; Vieira, I.C.; Panzoldo, N.B.; D´Alexandri, F.L.; Quintão, E.C.R. & Faria, E.C. Chemical modification of high density lipoprotein subfractions – HDL2 and HDL3 – after use of atorvastatin. Int. J. Clin. Pharmacol. Ther., 52(4): 277-283, 2014.

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Prof. Dr. Norberto Cysne Coimbra

  1. De Freitas, R.L.; De Oliveira, R.C.; De Oliveira, R.; Paschoalin-Maurin, T.; Corrêa, F.M.A. & Coimbra, N.C. The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT(2)A and 5-HT(2)C serotonergic receptors in post-ictal antinociception. Synapse, 68(1): 16-30, 2014.

  2. De Freitas, R.L.; Salgado-Rohner, C.J.; Biagioni, A.F.; Medeiros, P.; Hallak, J.E.C.; Crippa, J.A.S. & Coimbra, N.C. NMDA and AMPA/kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus. Cereb. Cortex, 24(6): 1518-1528, 2014.

  3. Gonçalves, T.C.T.; Londe, A.K.; Albano, R.I.P.; Araújo Junior, A.T.; Azeredo, M.A.; Biagioni, A.F.; Vasconcellos, T.H.F.; Ferreira, C.M.R.; Teixeira, D.G.; Crippa, J.A.S.; Vieira, D. & Coimbra, N.C. Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system. J. Neurol. Sci., 347(1-2): 82-89, 2014.

  4. Linares, I.M.P.; Jackowski, A.P.; Trzesniak, C.M.F.; Arrais, K.C.; Chagas, M.H.N.; Sato, J.R.; Santos, A.C.; Hallak, J.E.C.; Zuardi, A.W.; Nardi, A.E.; Coimbra, N.C. & Crippa, J.A.S. Cortical thinning of the right anterior cingulate cortex in spider phobia: A magnetic resonance imaging and spectroscopy study. Brain Res., 1576: 35-42, 2014.

  5. Mazzei-Silva, E.C.; De Oliveira, R.C.; Dos Anjos Garcia, T.; Falconi-Sobrinho, L.L.; Almada, R.C. & Coimbra, N.C. Intrinsic connections within the pedunculopontine tegmental nucleus are critical to the elaboration of post-ictal antinociception. Synapse, 68(8): 369-377,2014.

Profa. Dra. Rita de Cássia Aleixo Tostes Passaglia

  1. Bruder-Nascimento, T.; Chinnasamy, P.; Riascos-Bernal, D. F.; Cau, S.B.; Callera, G.E.; Touyz, R.M.; Tostes, R.C. & Sibinga, N.E.S. Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. J. Mol. Cell Cardiol., 66: 18-26, 2014.

  2. Bruder-Nascimento, T.; Silva, M.A.B. & Tostes, R.C. The involvement of aldosterone on vascular insulin resistance: implications in obesity and type 2 diabetes. Diabetol. & Metab. Syndr., 6(1): 90-98, 2014.

  3. Ceravolo, G.S.; Montezano, A.C.; Jordão, M.T.; Akamine, E. H.; Costa, T.J.; Takano, A.P.; Fernandes, D.C.; Barreto-Chaves, M.L.; Laurindo, F.R.; Tostes, R.C.; Fortes, Z.B.; Chopard, R.P.; Touyz, R.M. & Carvalho, M.H.C. An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: In vivo and In vitro studies. PLoS One, 9(11): e111117, 2014.

  4. Giachini, F.R.; Leite, R.; Osmond, D.A.; Lima, V.V.; Inscho, E. W.; Webb, R.C. & Tostes, R.C. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats. PLoS One, 9(3): e91890, 2014.

  5. Lima, V.V.; Lobato, N.S.; Filgueira, F.P.; Webb, R.C.; Tostes, R.C. & Giachini, F.R. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain. Braz. J. Med. Biol. Res., 47(10): 826-833, 2014.

  6. Lopes, R.A.M.; Neves, K.B.; Pestana, C.R.; Queiroz, A.L.; Zanotto, C.Z.; Chignalia, A.Z.; Valim, Y.M.; Silveira, L.R.; Curti, C. & Tostes, R.C. Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. Am. J. Physiol. Heart Circ. Physiol., 306(11): H1485-H1494, 2014.

  7. Matsumoto, T.; Lopes, R.A.M.; Taguchi, K.; Kobayashi, T. & Tostes, R.C. Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sci., 118(2): 129-135, 2014.

  8. Neves, K.B.; Lobato, N.S.; Lopes, R.A.M.; Filgueira, F.P.; Zanotto, C.Z.; De Oliveira, A.M. & Tostes, R.C. Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity? Clin. Sci. (Lond), 127 (2): 111-122, 2014.

  9. Santos, P.P.; Rafacho, B.P.M.; Gonçalves A.F.; Jaldin, R.G.; Bruder-Nascimento, T.; Silva, M.A.B.; Cau, S.B.A.; Roscani, M.G.; Azevedo, P.S.; Minicucci, M.F.; Tostes R.C.; Zornoff, L. A.M. & Paiva, S.A.R. Vitamin D induces increased systolic arterial pressure via vascular reactivity and mechanical properties. PLoS One, 9(6): e98895, 2014.

Prof. Dr. Thiago Mattar Cunha

  1. Aguiar, C.J.; Rocha-Franco, J.A.; Sousa, P.A.; Santos, A.K.; Ladeira, M.; Rocha-Resende, C.; Ladeira, L.O.; Resende, R.R.; Botoni, F.A.; Melo, M.B.; Lima, C.X.; Carballido, J.M.; Cunha, T.M.; Menezes, G.B.; Guatinosim, S. & Leite, M.F. Succinate causes pathological cardiomyocyte hypertrophy througfh GPR91 activation. Cell. Communic. & Signal., 12(1): 78-94, 2014.

  2. Barbosa, A.L.R.; Sousa, R.B.;Torres, J.N.L.; Cunha, T.M.; Cunha, F.Q.; Soares, P.M.G.; Ribeiro. R.A.; Vale, M.L. & Souza, M.H.L.P. Colitis generates remote antinociception in rats: the role of the L-arginine/NO/cGMP/PKG/KATP pathway and involvement of cannabinoid and opioid systems. Inflamm. Res., 63(12): 969-977, 2014.

  3. Barragán-Iglesias, P.; Rocha-González, H.I.; Pineda-Farias, J. B.; Murbartián, J.; Godínez-Chaparro, B.; Reinach, P.S.; Cunha, T.M.; Cunha, F.Q. & Granados-Soto, V. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. Eur. J. Pharmacol., 738: 91-100, 2014.

  4. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66 (7): 1009-1020, 2014.

  5. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R.D.R.; Martins-Pinge, M.C.; Tatakihara, R.I.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr.: Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice. Physiol. & Behav., 128: 277-287, 2014.

  6. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  7. Figueiredo, S.A.; Vilela, F.M.P.; Silva, C.A.; Cunha, T.M.; Santos, M.H. & Fonseca, M.J.V. In vitro and in vivo photoprotective/photochemopreventive potential of Garcinia brasiliensis epicarp extract. J. Photochem. Photobiol. B: Biol., 131: 65-73. 2014.

  8. Ivan, A.L.M.; Campanini, M.Z.; Martinez, R.M.; Ferreira, V.S.; Steffen, V.S.; Vicentini, F.T.M.C.; Vilela, F.M.P.; Martins, F.S.; Zarpelon, A.C.; Cunha, T.M.; Fonseca, M.J.V.; Baracat, M.M.; Georgetti, S.R. & Verri, W.A., Jr. Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro. J. Photochem. Photobiol. B: Biol. 138: 124-133, 2014.

  9. Leite, A.C.R.M.;Teotonio, M.A.A.; Girão, V.C.C.; Pompeu, M.M.L.; Nunes, R.M.; Cunha, T.M.; Pinto, A.C.M.D.; Cunha, F.Q. & Rocha, F.A.C. Meniscal transaction rather than excision increases pain behavior and structural damage in experimental osteoarthritis in mice. Osteoarth. Cartilage, 22(11):1878-1885, 2014.

  10. Moriconi, A.; Cunha, T.M.; Souza, G.R.; Lopes, A.H.; Cunha, F.Q.; Carneiro, V. L.; Pinto, L.G.; Brandolini, L.; Aramini, A.; Bizzarri, C.; Bianchini, G.; Beccari, A.R.; Fanton, M.; Bruno, A.; Costantino, G.; Bertini, R.; Galliera, E.; Locati, M.; Ferreira, S.H.; Teixeira, M.M. & Allegretti, M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc. Natl. Acad. Sci. U S A., 111(47): 16937-16942, 2014.

  11. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.

  12. Vieira, S.M.; Silva, R.L.; Lemos, H.P.; Amorim, R.C.N.; Silva, E.C.C.; Reinach, P.S.; Cunha, F.Q.; Pohlit, A.M. & Cunha, T. M. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, 95: 8-15, 2014.

Prof. Dr. Sérgio Henrique Ferreira

  1. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R. D.R.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. J. Pharm. Pharmacol., 66 (7): 1009-1020, 2014.

  2. Borghi, S.M.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Cardoso, R.D.R.; Martins-Pinge, M.C.; Tatakihara, R.I.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri, W.A., Jr.: Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice. Physiol. & Behav., 128: 277-287, 2014.

  3. Calil, I.L.; Zarpelon, A.C.; Guerrero, A.T.G.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Cunha, T.M. & Verri, W. A., Jr. Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS One, 9(3): e90013, 2014.

  4. Ferrari, L.F.; Lotufo, C.M.; Araldi, D.; Rodrigues, M.A.; Macedo L.P.; Ferreira, S.H. & Parada, C.A. Inflammatory sensitization of nociceptors dependes on activation of NMDA receptors in DRG satellite cells. Proc. Natl. Acad. Sci. U S A., 111(51): 18363-18368, 2014.

  5. Garrido-Suárez, B.B.; Garrido, G.; Castro-Labrada, M.; Merino, N.; Valdés, O.; Rodeiro, I.; Hernandez, I.; Godoy-Figueiredo, J.; Ferreira, S.H. & Delgado-Hernández, R. Anti-hypernociceptive effect of mangiferin in persistent and neuropathic pain models in rats. Pharmacol. Biochem. Behav., 124: 311-319, 2014.

  6. Malvar, D.C.; Aguiar, F.A.; Vaz, A.L.L.; Assis, D.C.R.; Melo, M.C.C.; Jabor, V.A.P.; Kalapothakis, E.; Ferreira, S.H.; Clososki, C. & Souza, G.E.P. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2-dependent and –independent fever while 4-AA only blocks PGE2-dependent fever. Brit. Pharmacol. Soc.; 171(5): 3666-3679, 2014.

  7. Moriconi, A.; Cunha, T.M.; Souza, G.R.; Lopes, A.H.; Cunha, F.Q.; Carneiro, V. L.; Pinto, L.G.; Brandolini, L.; Aramini, A.; Bizzarri, C.; Bianchini, G.; Beccari, A.R.; Fanton, M.; Bruno, A.; Costantino, G.; Bertini, R.; Galliera, E.; Locati, M.; Ferreira, S.H.; Teixeira, M.M. & Allegretti, M. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc. Natl. Acad. Sci. U S A., 111(47): 16937-16942, 2014.

  8. Staurengo-Ferrari, L.; Zarpelon, A.C.; Longhi-Balbinot, D.T.; Marchesi, M.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Ferreira, S.H.; Casagrande, R.; Miranda, K.M. & Verri, W.A., Jr. Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacol. Rep., 66(4): 691-698, 2014.