Publicaciones

En esta página: publicaciones Año 2015

Prof. Dr. Alexandre Pinto Corrado

  1. Prado, W. A.; Rossaneis, A. C.; Carvalho, I.; Zamoner, L. O. & Corrado, A. P.: Neamine and 2-deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic pain. J Pharm Pharmacol., 67, 1696-1704.

  2. Oliveira, L.; Costa, A. C.; Noronha-Matos, J. B.; Silva, I.; Cavalcante, W. L.; Timoteo, M. A.; Corrado, A. P.; Dal Belo, C. A.; Ambiel, C. R.; Alves-Do-Prado, W. & Correia-De-Sa, P.: Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A2A receptors and redistribution of synaptic vesicles. Neuropharmacology. v.89 64-76.

Profa. Dra. Alline Cristina de Campos

  1. De Miranda, A. S.; Brant, F.; Campos, A. C.; Vieira, L. B.; Rocha, N. P.; Cisalpino, D.; Binda, N. S.; Rodrigues, D. H.; Ransohoff, R. M.; Machado, F. S.; Rachid, M. A. & Teixeira, A. L.: Evidence for the contribution of adult neurogenesis and hippocampal cell death in experimental cerebral malaria cognitive outcome. Neuroscience. v.284 920-33.

  2. Lima, I. V.; Campos, A. C.; Miranda, A. S.; Vieira, E. L.; Amaral-Martins, F.; Vago, J. P.; Santos, R. P.; Sousa, L. P.; Vieira, L. B.; Teixeira, M. M.; Fiebich, B. L.; Moraes, M. F.; Teixeira, A. L. & De Oliveira, A. C.: PI3Kgamma deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. Exp Neurol. v.267 123-34.

  3. Campos, A. C.; Brant, F.; Miranda, A. S.; Machado, F. S. & Teixeira, A. L.: Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience. v.289 166-80.

Prof. Dr. Fernando de Queiróz Cunha

  1. Bassi, G.S.; Brognara, F.; Castania, J.A.; Talbot, J.; Cunha, T.M.; Cunha, F.Q.; Ulloa, L.; Kanashiro, A.; Dias, D.P.M. & Salgado, H.C. Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function. Brain, Behavior & Immunity, 49: 140-147, 2015

  2. Borghi, S.M.; Pinho-Ribeiro, F.A.; Zarpelon, A.C.; Cunha, T.M.; Alves-Filho, J.C.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice. Exp. Physiol., 100(5): 531-544, 2015.

  3. Cardoso, C.P.; De Oliveira, A.J.A.; Botoni, F.A.; Rezende, I.C.P.; Alves-Filho, J.C.; Cunha, F.Q.; Estanislau, J.A.S.; Magno, L.A.V. & Rios-Santos, F. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock. Mem. Inst. Oswaldo Cruz, RJ, 110(4): 453-460, 2015.

  4. Carlos, D.; Yaochite, J.N.U.; Rocha, F.A.; Toso, V.D.; Malmegrim, K.C.R.; Ramos, S.G.; Jamur, M.C.; Oliver, C.; Camara, N.O.; Andrade, M.V.M.; Cunha F.Q. & Silva, J.S. Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice. Eur. J. Immunol., 45(10): 2873-2885, 2015.

  5. Carregaro, V.; Ribeiro, J.M.; Valenzuela, J.G.; Souza-Júnior, D.L.; Costa, D.L.; Oliveira, C.J.F.; Sacramento, L.A.; Nascimento, M.S.L.; Milanezi, C.M.; Cunha, F.Q. & Silva, J.S. Nucleosides present of phlebotomine saliva induce immunossuppression and promote the infection establishment. PLoS Negl. Trop. Dis., 9(4): e0003600, pgs: 1 a 21, 2015.

  6. Carvalho, T.T.; Borghi, S.M.; Pinho-Ribeiro, F.A.; Mizokami, S.S.; Cunha, T.M.; Ferreira, S.H.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: role for peripheral TNFα, IL-1β and IL-10. Eur. J. Pharmacol., 749: 62-72, 2015.

  7. Conte, F.P.; Ferraris, F.K.; Costa, T.E.M.M.; Pacheco, P.; Seito, L.N.; Verri Jr., W.A.; Cunha, F.Q.; Penido, C. & Henriques, M.G. Effect of gedunin on acute articular inflammation and hypernociception in mice. Molecules 20(2): 2636-2657, 2015.

  8. Fattori, V.; Pinho-Ribeiro, F.A.; Borghi,S.M.; Alves-Filho, J.C.; Cunha, T.M.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NK-кB activation. Inflamm. Res., 64(12): 993-1003, 2015.

  9. Freitas, C.S.; Roveda, A.C., Jr.; Truzzi, D.R.; Garcia, A.C.; Cunha, T.M.; Cunha, F.Q. & Franco, D.W. Anti-inflammatory and anti-nociceptive activity of ruthenium complexes with isonicotinic and nicotinic acids (Niacin) as ligands. J. Med. Chem., 58(11): 4439-4448, 2015.

  10. Gaspar-Elsas, M.I.; Queto, T.; Masid-de-Brito, D.; Vieira, B.M.; De Luca, B.; Cunha, F.Q. & Xavier-Elsas, P. α-Galactosylceramide suppresses murine eosinophil production through interferon-y-dependent induction of NO synthase and CD95. Br. J. Pharmacol., 172(13): 3313-3325, 2015.

  11. Leite, C.A.V.G.; Alencar, V.T.L.; Melo, D.L.R.; Mota, J.M.S.C.; Melo, P.H.; Mourão, L.T.C.; Wong, D.V.T.; Magalhães, P.J.C.; Santos, A.A.; Brito, G.A.C.; Lima-Júnior, R.C.P.; Cunha, F.Q. & Ribeiro, R.A. Target inhibition of IL-1 receptor prevents ifosfamide induced hemorrhagic cystitis in mice. J. Urol., 194(6): 1777-1786, 2015.

  12. Molinaro, R.; Pecli, C.; Guilherme, R.F.; Alves-Filho, J.C.; Cunha, F.Q.; Canetti, C.; Kunkel, S.L.; Bozza, M.T. & Benjamim, C.F. CCR4 controls the suppressive effects of regulatory T cells on early and late events during severe sepsis. PLoS ONE, 10(7): e0133227, 1-21, 2015.

  13. Moura, J.F.B.; Mota, J.M.S.C.; Leite, C.A.V.; Wong, D.V.T.; Bezerra, N.P.; Brito, G.A.C.; Lima, V.; Cunha, F.Q. & Ribeiro, R.A. A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide. Int. J. Radiat. Biol., 91(6): 500-509, 2015.

  14. Nunes, R.M.; Martins, M.R.; Silva-Junior, F.S..; Leite, A.C.R.M.; Girão, V.C.C.; Cunha, F.Q.; Marinho, A.L.L.F.; Pinto, A.C.M.D. & Rocha, F.A.C. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflamm. Res., 64(10): 781-787, 2015.

  15. Peres. R.S.; Liew, F.Y.; Talbot, J.; Carregaro, V.; Oliveira, R.D.; Almeida, S.L.; França R.F.O.; Donate, P.B.; Pinto, L.G.; Ferreira, F.I.S.; Costa, D.L.; Demarque, D.P.; Gouvea, D.R.; Lopes, N.P.; Queiroz, R.H.C.; Silva, J.S.; Figueiredo, F.; Alves-Filho, J.C.; Cunha, T.M.; Ferreira, S.H.;; Louzada-Junior, P. & Cunha, F.Q. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. PNAS 112(8): 2509-2514, 2015.

  16. Pinto, L.G.; Talbot, J.; Peres, R.S.; França, R.F.; Ferreira, S.H.; Ryffel, B.; Alves-Filho, J.C.; Figueiredo, F.; Cunha, T.M. & Cunha, F.Q. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production. Arthritis Res. & Therapy, 17(1): 235: 1-13, 2015.

  17. Ruiz-Miyazawa, K.W.; Pinho-Ribeiro, F.a.; Zarpelon, A.C.; Staurengo-Ferrari, L.; Silva, R.L.; Alves-Filho, J.C.; Cunha, T.M.; Cunha. F.Q.; Casagrande, R. & Verri Jr., W.A. Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-кB. Chem. Biol. Interact., 237: 9-17, 2015.

  18. Sacramento, L.; Trevelin, S.c.; Nascimento, M.S.; Lima-Júnior, D.S.; Costa, D.L.; Almeida, R.P.; Cunha, F.Q.; Silva, J.S. & Carregaro, V. Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection. Infect. Immun., 83(12): 4604-4616, 2015.

  19. Serafim, K.G.G.; Navarro, S.A.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Fattori, V.; Cunha, T.M.; Alves-Filho, J.C.; Cunha, F.Q.; Casagrande, R. & Verri Jr., W.A. Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice. Naunyn-Schmiedeb. Arch. Pharmacol., 388(11): 1211-1221, 2015.

  20. Souza, G.R.; Cunha, T.M.; Silva, R.L.; Lotufo, C.M.; Verri, W.A., Jr.; Funez, M.I.; Villarreal, C.F.; Talbot, J.; Sousa, L.P.; Parada, C.A.; Cunha, F.Q. & Ferreira, S.H. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacol. Biochem. & Beh., 134: 49-56, 2015.

  21. Wong, D.V.T.; Lima-Júnior, R.C.P.; Carvalho, C.B.M.; Borges, V.F.; Wanderley, C.W.S.; Bem, A.X.C.; Leite, C.A.V.G.; Teixeira, M.A.; Batista, G.L.P.; Silva, R.L.; Cunha, T.M.; Brito, G.A.C.; Almeida, P.R.C.; Cunha, F.Q. & Ribeiro, R.A. The adaptor protein Myd88 is a key signaling molecule in the pathogenesis of irinotecan-induced intestinal mucositis. PLoS One 10(10): e0139985, 1-21, 2015.

  22. Xavier-Elsas, P.; De Luca, B.; Queto, T.; Vieira, B.M.; Masid-de-Brito, D.; Dahab, E.C.; Alves-Filho, J.C.F.; Cunha, F.Q. & Gaspar-Elsas, M.I.C. Blockage of eosinopoiesis by IL-17A is prevented by cytokine and lipid mediators of allergic inflammation. Med. Inflamm.; Volume 2015, Article ID 968932: 1-11, 2015.

Prof. Dr. Fernando Morgan de Aguiar Corrêa

  1. Fassini, A.; Scopinho, A.A.; Resstel, L.B.M. & Corrêa, F.M.A. k-Opioid receptors in the infralimbic córtex modulate the cardiovascular resnses to acute stress. Exp. Physiol.; 100(4): 377-387, 2015.

  2. Fortaleza, E.A.T.; Ferreira-Junior, N.C.; La Gatta, D.C.; Resstel, L.B.M. & Corrêa, F.M.A. The medial amygdaloid nucleus modulates the baroreflex activity in conscious rats. Auton. Neurosci., 193: 44-50, 2015.

  3. Pelosi, G.G.; Busnardo, C.; Tavares, R.F. & Corrêa, F.M.A. Involvement of non-NMDA glutamate receptors of the hypothalamic paraventgricular nucleus in the cardiovascular response to the microinjection of noradrenaline into the dorsal periaqueductal gray area of rats. Brain Res., 1602: 96-105, 2015.

  4. Stanquini, L.A.; Resstel, L.B.M.; Corrêa, F.M.A.; Joca, S.R.L. & Scopinho, A.A. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacol., Biochem. Beh., 136: 31-38, 2015.

Prof. Dr. Fernando Silva Carneiro

  1. Muniz, J. J.; Leite, L. N.; De Martinis, B. S.; Carneiro, F. S. & Tirapelli, C. R.: Chronic ethanol consumption induces erectile dysfunction: Role of oxidative stress. Life Sci. v.141 44-53.

  2. Rodrigues, F. L.; Silva, L. E.; Hott, S. C.; Bomfim, G. F.; Da Silva, C. A.; Fazan, R., Jr.; Resstel, L. B.; Tostes, R. C. & Carneiro, F. S.: Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure. Am J Physiol Regul Integr Comp Physiol. v.308 (8): R714-23.

Prof. Dr. Gustavo Ballejo Olivera

  1. Alves Filho, F.; Cavalcanti, P. M.; Passaglia R de, C. & Ballejo, G.: Long-lasting endothelium-dependent relaxation of isolated arteries caused by an extract from the bark of Combretum leprosum. Einstein (Sao Paulo). v.13 (3): 395-403.

Prof. Dr. Hélio Zangrossi Júnior

  1. Bulos, E.M.; Pobbe, R.L.H. & Zangrossi, H., Jr. Behavioral consequences of predator stress in the rat elevated T-maze. Physiol. Behav., 146: 28-35, 2015.

  2. Casarotto, P.C.; dos Santos, P.C.; Lucas, G.A.; Biojone, C.; Pobbe, R.L.H.; Vilela-Costa, H.H.; Joca, S.R.L.; Guimarães, F.S. & Zangrossi, H., Jr. BDNF-TRKB signaling system of the dorsal periaqueductal Gray matter is implicated in the panicolytic-like effect of antidepressant drugs. Eur. Neuropsychopharmacol., 25(6): 913-922, 2015.

  3. Graeff, F.G.; Sant´Anna A.B.; Vilela-Costa, H.H. & Zangrossi, H., Jr. New findings on the neurotransmitter modulation of defense in the dorsal periaqueductal gray. CNS Neurol. Disord. Drug Targets, 14(8): 988-995, 2015.

  4. Roncon, C.M.; Almada, R.C.; Maraschin, J.C.; Audi, E.A.; Zangrossi, H., Jr.; Graeff, F.G. & Coimbra, N.C. Pharmacological evidence for the mediation of the panicolytic effect of fluoxetine by dorsal periaqueductal gray matter µ-opioid receptors. Neuropharmacol., 99: 620-626, 2015.

  5. Spiacci, A. Jr.; De-Oliveira-Sérgio, T.; Da Silva, G.S.F.; Glass, M.L.; Schenberg, L.C.; Garcia-Cairasco, N. & Zangrossi, H., Jr. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. Neuroscience, 307: 191-198, 2015.

Prof. Dr. José Carlos Farias Alves Filho

  1. Talbot, J.; Bianchini, F.J.; Nascimento, D.C.; Oliveira, R.D.R.; Souto, F.O.; Pinto, L.G.; Peres, R.S.; Silva, J.R.; Almeida, S.C.L.; Louzada-Junior, P.; Cunha, T.M.; Cunha, F.Q. & Alves-Filho, J.C. CCR2 expression in neutrophils plays a critical role in their migration into the joints in rheumatoid arthritis. Arth. & Rheumat., 67(7): 1751-1759, 2015.

  2. Veras, F.P.; Peres, R.S.; Saraiva, A.L.L.; Pinto, L.G.; Louzada-Junior, P.; Cunha, T.M.; Paschoal, J.A.R.; Cunha, F.Q. & Alves-Filho, J.C. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. Sci Rep., 5: 15171 (1 a 11), 2015.

Prof. Dr. José Eduardo Tanus dos Santos

  1. 1. Amaral, J.H.; Ferreira, G.C.; Pinheiro, L.C.; Montenegro, M.F. & Tanus-Santos, J.E. Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. Redox Biol., 5: 340-346, 2015.

  2. Barbaro, N.R.; Araujo, T.M.; Tanus-Santos, J.E.; Anhê, G.F.; Fontana, V. & Moreno, H. Vascular damage in resistant hypertension: TNF-alpha inhibition effects on endothelial cells. Biomed. Res. Int., vol. 2015, Article ID 631594 (1-8), 2015.

  3. Barcelos, G.R.M.; De Marco, K.C.; De Rezende, V.B.; Braga, G.U.L.; Antunes, L.M.G.; Tanus-Santos, J.E. & Barbosa Jr., F. Genetic effects of eNOS polymorphisms on biomarkers related to cardiovascular status in a population coexposed to methylmercury and lead. Arch. Environ. Contam. Toxicol., 69(2): 173-180, 2015.

  4. Belo, V.A.; Lacchini, R.; Miranda, J.A.; Lanna, C.M.M.; Souza-Costa, D.C. & Tanus-Santos, J.E. Increased activity of MMP-2 in hypertensive obese children is associated with hypoadiponectinemia. Obesity, 23(1): 177-182, 2015.

  5. Belo, V.A.; Luizon, M.R.; Lacchini, R.; Miranda, J.A.; Lanna, C.M.M.; Souza-Costa, D.C. & Tanus-Santos, J.E. The effects of NAMPT haplotypes and metabolic risk factors on circulating visfatin/NAMPT levels in childhood obesity. Internat. J. Obesity, 39(1): 130-135, 2015.

  6. Cau, S.B.A.; Guimarães, D.A.; Rizzi, E.; Ceron, C.S.; Gerlach, R.F. & Tanus-Santos, J.E. The nuclear factor kappaB inhibitor pyrrolidine dithiocarbamate prevents cardiac remodeling and matrix metalloproteinase-2 Up-regulation in renovascular hypertension. Basic & Clinical Pharmacol. & Toxicol.,117(4): 234-241, 2015.

  7. De Faria, A.P.C.; Modolo, R.; Sabbatini, A.R.; Barbaro, N.R.; Corrêa, N.B.; Brunelli, V.; Tanus-Santos, J.E.; Fontana, V. & Moreno, H. Adiponectin -11377C/G and +276G/T polymorphisms affect adiponectin levels but do not modify Responsiveness to therapy in resistant hypertension. Basic & Clinical Pharmacol. & Toxicol., 117(1): 65-72, 2015.

  8. De Miranda, J.A.; Lacchini, R.; Belo, V.A.; Lanna, C.M.M.; Sertorio, J.T.; Luizon, M.R. & Tanus-Santos, J.E. The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents. J. Human Hypertens., 29(2): 109-114, 2015.

  9. Eleutério, N.M.; Palei, A.C.T.; Rangel Machado, J.S.; Tanus-Santos, J.E.; Cavalli, R.C. & Sandrim, V.C. Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant. Pregnancy Hypertens., 5(2): 205-208, 2015.

  10. Guimarães, D.A. & Tanus-Santos, J.E.. Combining drugs to optimize the therapy of hypertension: experimental evidence derived from animal models. Hypertension Res., 38(7): 457-458, 2015.

  11. Guimarães, D.A.; Rizzi, E.; Ceron, C.S.; Martins-Oliveira, A.; Gerlach, R.F.; Shiva, S. & Tanus-Santos, J.E. Atorvastatin and sildenafil decrease vascular TGF-β levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension. Redox Biol., 6: 386-395, 2015.

  12. Lacchini, R.; Muniz, J.J.; Nobre, Y.T.D.A.; Cologna, A.J.; Martins, A.C.P. & Tanus-Santos, J.E. Relationship between arginase 1 and arginase 2 levels and genetic polymorphisms with erectile dysfunction. Nitric Oxide, 51: 36-42, 2015.

  13. Luizon, M.R.; Belo, V.A.; Palei, A.C.T.;Amaral, L.M.; Lacchini, R.; Sandrim, V.C.; Duarte, G.; Cavalli, R.C. & Tanus-Santos, J.E. Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy. Hypertension Res., 38(5): 361-366, 2015.

  14. Oliveira-Paula, G.H.; Lacchini, R.; Fontana, V.; Silva, P.S.; Biagi, C. & Tanus-Santos, J.E. Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril. Eur. J. Clin. Pharmacol., 71(8): 949-957, 2015.

  15. Pinheiro, L.C.; Amaral, J.H.; Ferreira, G.C.; Portella, R.L.; Ceron, C.S.; Montenegro, M.F.; Toledo Jr., J.C. & Tanus-Santos, J.E. Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension. Free Radic. Biol. Med., 87: 252-262, 2015.

  16. Rezende, V.B.; Barbosa Jr., F.; Palei, A.C.T.; Cavalli, R.C.; Tanus-Santos, J.E. & Sandrim, V.C. Correlations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancy. J. Trace Elem. Med. Biol., 29: 130-135, 2015.

  17. Rocha, M.G.; Gomes, V.A.; Tanus-Santos, J.E.; Rosa-e-Silva, J.C.; Candido-dos-Reis, F.J.; Nogueira, A.A. & Poli-Neto, O.B. Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis. Braz. J. Med. Biol. Res., 48(4): 363-369, 2015.

  18. Sandrim, V.C.; Palei, A.C.T.; Eleuterio, N.; Tanus-Santos, J.E. & Cavalli, R.C. Antihypertensive therapy in preeclampsia is not modulated by VEGF polymorphisms. Arch. Gynecol. Obstet, 291(4): 799-803, 2015.

Prof. Dr. Leonardo Resstel Barbosa Moraes

  1. Fassini, A.; Antero, L.S.; Corrêa, F.M.A.; Joca, S.R.L. & Resstel, L.B.M. The prelimbic córtex muscarinic M3 receptor-nitric oxide-guanylyl cyclase pathway modulates cardiovascular responses in rats. J. Neurosc. Res., 93(5): 830-838, 2015.

  2. Lagatta, D.C.; Ferreira-Junior, N.C. & Resstel, L.B.M. Medial prefrontal córtex TRPV1 channels modulate the baroreflex cardiac activity in rats. Br. J. Pharmacol., 172: 5377-5389, 2015.

  3. Lisboa, S.F.; Borges, A.A.; Nejo, P.; Fassini, A.; Guimarães, F.S. & Ressel, L.B.M. Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefronal córtex modulate anxiety-lkike behavior in rats: Additional evidence. Prog. Neuro-Psychopharmacol. & Biol. Psychiatry, 59: 76-83, 2015.

  4. Lisboa, S.F.; Gomes, F.V.; Silva, A.L.S.; Uliana, D.L.; Camargo, L.H.A.; Guimarães, F.S.; Cunha, F.Q.; Joca, S.R.L. & Resstel, L.B.M. Increased contextual fear conditioning in iNOS knockout mice: Additional evidence for the involvement of nitric oxide in stress-related disorders and contribution of the endocannabinoid system. Int. J. Neuropsyhopharmacol., 18(8): 1-12, 2015.

  5. Simplicio, J.A.; Resstel, L.B.M.; Tirapelli, D.P.C.; D´Orléans-Juste, P. & Tirapelli, C.R. Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vasc. Pharmacol., 73: 124-137, 2015.

  6. Stanquini, L.A.; Resstel, L.B.M.; Corrêa, F.M.A.; Joca, S.R.L. & Scopinho, A.A. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacol., Biochem. Beh., 136: 31-38, 2015.

  7. Viana, T.G.; Hott, S.C.; Resstel, L.B.M.; Aguiar, D.C. & Moreira, F.A. Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats. Psychopharmacol., 232(9): 1545-1553, 2015.

Profa. Dra. Michele Mazzaron de Castro

  1. Belo, V.A. & Castro, M.M. Matrix metalloproteinases and the vascular smooth muscle cell migration in hypertension. Diabesity 1(2): 15-17, 2015.

  2. Belo, V.A.; Guimarães, D.A. Castro, M.M. Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension. J. Vasc. Res., 52(4): 221-231, 2015.

Prof. Dr. Norberto Cysne Coimbra

  1. Almada, R.C. & Coimbra, N.C. Recruitment os striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae). Synapse 69(6): 299-313, 2015.

  2. Almada, R.C.; Coimbra, N.C. & Brandão, M.L. Medial prefrontal córtex serotonergic and GABAergic mechanisms modulate the expression of contextual fear: intraatelencephalic pathways and differential involvement of cortical subregions. Neurosc., 284: 988-997, 2015.

  3. Almada, R.C.; Roncon, C.M.; Elias-Filho, D.H. & Coimbra, N.C. Endocammabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by Urutu-cruzeiro venomous pit viper. Neurosc., 303: 503-514, 2015.

  4. Roncon, C.M.; Almada, R.C.; Maraschin, J.C.; Audi, E.A.; Zangrossi, H., Jr.; Graeff, F.G. & Coimbra, N.C. Pharmacological evidence for the mediation of the panicolytic effect of fluoxetine by dorsal periaqueductal gray matter µ-opioid receptors. Neuropharmacol., 99: 620-626, 2015.

  5. Silva, J.A.; Biagioni, A.F.; Almada, R.C.; Crippa, J.A.S.; Hallak,. J.E.C.; Zuardi, A.W. & Coimbra, N.C. Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulate, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon. Eur. J. Pharmacol., 758: 153-163, 2015.

  6. Twardowschy, A. & Coimbra, N.C. µ- and к-Opioid receptor activation in the dorsal periaqueductal grey matter differentially modulates panic-like behaviours induced by electrical and chemical stimulation of the inferior colliculus. Brain Res., 1597: 168-179, 2015.

  7. Ullah, F.; Dos Anjos-Garcia, T.; Santos, I.R.; Biagioni, A.F. & Coimbra, N.C. Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors. Beh. Brain Res., 293: 143-152, 2015.

Profa. Dra. Rita de Cássia Aleixo Tostes Passaglia

  1. Bomfim, G.F.; Echem, E.; Martins, C.B.; Costa, T.J.; Sartoretto, S.M.; Dos Santos, R.A.; Oliveira, M.A.; Akamine, E.H.; Fortes, Z.B.; Tostes, R.C.; Webb, R.C. & Carvalho, M.H.C. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci., 122: 1-7, 2015.

  2. Bruder-Nascimento, T.; Callera, G.E.; Montezano, A.C.; He, Y.; Antunes, T.T.; Cat, A.N.; Tostes, R.C. & Touyz, R.M. Vascular injury in diabetic dB/dB mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways. Clin. Sci. (Lond)., 128(7): 411-423, 2015.

  3. Chignalia, A.Z.; De Oliveira, M.A.; Debbas, V.; Dull, R.O.; Laurindo, F.R.M.; Touyz, R.M.; Carvalho, M.H.C.; Fortes, Z.B. & Tostes, R.C. Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms. Clin. Sci., 129(1): 39-48, 2015.

  4. Costa, T.J.; Ceravolo, G.S.; Dos Santos, R.A.; De Oliveira, M.A.; Araújo, P.X.; Giaquinto, L.R.; Tostes, R.C.; Akamine, E.H.; Fortes, Z.B.; Dantas, A.P. & Carvalho, M.H.C. Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells. Am. J. Physiol. Heart Circ. Physiol., 308(7): H723-H732, 2015.

  5. Ferreira, N.S.; Cau, S.B.A.; Silva, M.A.B.; Manzato, C.P.; Mestriner, F.L.A.C.; Matsumoto,T.; Carneiro, F.S. & Tostes, R.C. Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation. Frontiers in Pharmacol., vol. 6, Article 34, pags. 1-12, 2015.

  6. Lopes, R.A.; Neves, K.B.; Tostes, R.C.; Montezano, A.C. & Touyz, R.M. Downregulation of nuclear factor erythroid 2-related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 66(6): 1240-1250, 2015.

  7. Matsumoto, T.; Goulopoulou, S.; Taguchi, K.; Tostes, R.C. & Kobayashi, T. Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Brit. J. Pharmacol., 172(16): 3980-4001, 2015.

  8. Neves, K.B.; Dinh Cat, A.N.; Lopes, R.A.M.; Rios, F.J.; Anagnostopoulou, A.; Lobato, N.S.; De Oliveira, A.M.; Tostes, R.C.; Montezano, A.C. & Touyz, R.M. Chemerin regulates crosstalk between adipocytes and vascular cells through nox. Hypertension, 66(3): 657-666, 2015.

  9. Pereira, C.A.; Ferreira, N.S.; Mestriner, F.L.; Antunes-Rodrigues, J.; Évora, P.R.B.; Resstel, L.B.M.; Carneiro, F.S. & Tostes, R.C. Chronic fluoxetine treatment increases NO bioavailability and calcium-sensitive potassium channels activation in rat mesenteric resistance arteries. Eur. J. Pharmacol., 765: 375-383, 2015.

  10. Rodrigues, F.L. Fais, R.S. Tostes, R.C. & Carneiro, F.S. There is a link between erectile dysfunction and heart failure: it could be inflammation. Curr. Drug Targets, 16(5): 442-450, 2015.

  11. Silva, M.A.B.; Brude-Nascimento, T.; Cau, S.B.A.; Lopes.,R.A.M.; Mestriner, F.L.A.C.; Fais, R.S.; Toyyz, R.M. & Tostes, R.C. Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling. Frontiers in Physiol., Vol. 6: Article 269 (1-11), 2015.

  12. Silva, M.A.B.; Cau, S.B.A.; Lopes, R.A.M.; Manzato, C.P.; Neves, K.B.; Bruder-Nascimento, T.; Mestriner, F.L.A.C.; Montezano, A.C.; Dinh Cat, A.N.; Touyz, R.M. & Tostes, R.C. Mineralocorticoid receptor blockade prevents vascular remodeling in a rodent model of type 2 diabetes mellitus. Clin. Sci., 129(7): 533-545, 2015.

Prof. Dr. Thiago Mattar Cunha

  1. Fonseca, M.D.; Cunha, F.Q.; Kashfi, K. & Cunha, T.M. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. Pharmacol. Res. Perspec., 3(3): e00133 (1-12), 2015.

  2. Lopes, A.H.; Talbot, J.; Silva, R.L.; Lima, J.B.; França, R.O.; Verri, W.A., Jr.; Mascarenhas, D.P.; Ryffel, B.; Cunha, F.Q.; Zamboni, D.S. & Cunha, T.M. Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain, 156(3): 451-459, 2015.

  3. Parra, R.S.; Lopes, A.H.; Carreira, E.U.; Feitosa, M.R.; Cunha, F.Q.; Garcia, S.B.; Cunha, T.M.; da Rocha, J.J.R. & Féres, O. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. Medical Gas Res., 5: 6 (1-9), 2015.

  4. Patricio, E.S.; Costa, R.; Figueiredo, C.P.; Gers-Barlag, K.; Bicca, M.A.; Manjavachi, M.N.; Segat, G.C.; Gentry, C.; Luiz, A.P.; Fernandes,. E.S.; Cunha, T.M.; Bevan, S. & Calixto, J.B. Mechanisms Underlying the scratching behavior induced by the activation of proteinase-activated receptor-4 in mice. J. Investig. Dermatol., 135(10): 2484-2491, 2015.

  5. Quadros, A.U.; Pinto, L.G.; Fonseca, M.M.; Kusuda, R.; Cunha, F.Q. & Cunha, T.M. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. Scientific Rep., 5: 14648 (1-11), 2015.

  6. Silva, R.L.; Lopes, A.H.; França, R.O.; Vieira, S.M.; Silva, E.C.C.; Amorim, R.C.N.; Cunha, F.Q.; Pohlit, A.M. & Cunha, T.M. The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation. J. Nat. Prod., 78(2): 241-249, 2015.

  7. Toller-Kawahisa, J.E.; Canicoba, N.C.; Venancio, V.P.; Kawahisa, R.; Antunes, L.M.G.; Cunha, T.M. & Marzocchi-Machado, C.M. Systemic lupus erythematosus onset in lupus-prone B6.MRL/lpr mice Is influenced by weight gain and Is preceded by an increase in neutrophil oxidative burst activity. Free Rad. Biol. Med., 86: 362-373, 2015.

  8. Vaz, E.R.; Fujimura, P.T.; Araujo, G.R.; Silva, C.A.T.; Silva, R.L.; Cunha, T.M.; Lopes-Ferreira, M.; Lima, C.; Ferreira, M.J.; Cunha-Junior, J.P.; Taketomi, E.A.; Goulart, L.R. & Ueira-Vieira, C. A short peptide that mimics the binding domain of TGF-β1 presents potent anti-inflammatory activity. PLoS One, 10(8): e0136116 (1-20), 2015.

  9. Yamacita-Borin, F.Y.; Zarpelon, A.C.; Pinho-Ribeiro, F.A.; Fattori, V.; Alves-Filho, J.C.; Cunha, F.Q.; Cunha, T.M.; Casagrande, R.; Verri, W.A., Jr. Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice. Neurosc. Let., 605: 53-58, 2015. R46.

Prof.Dr.Wiliam Alves do Prado

  1. Mathes, C.; Melero, A.; Conrad, P.; Vogt, T.; Rigo, L.; Selzer, D.; Prado, W. A.; De Rossi, C.; Garrigues, T. M.; Hansen, S.; Guterres, S. S.; Pohlmann, A. R.; Beck, R. C.; Lehr, C. M. & Schaefer, U. F.: Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects. J Control Release. v.223 207-14.

  2. Reis, G. M.; Fais, R. S. & Prado, W. A.: The antinociceptive effect of stimulating the retrosplenial cortex in the rat tail-flick test but not in the formalin test involves the rostral anterior cingulate cortex. Pharmacol Biochem Behav. v.131 112-8.

  3. Rossaneis, A. C.; Genaro, K.; Dias, Q. M.; Guethe, L. M.; Fais, R. S.; Del Bel, E. A. & Prado, W. A.: Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats. Eur J Pain. v.19 (8): 1148-57.

  4. Rossaneis, A. C. & Prado, W. A.: The ventral portion of the anterior pretectal nucleus controls descending mechanisms that initiate neuropathic pain in rats. Clin Exp Pharmacol Physiol. v.42 (6): 704-10.